Hereditary hemochromatosis (HH) is a disease of iron overload leading to the accumulation of iron in specific organs including the liver, heart, pancreas and gonads. From:The International Journal of Biochemistry & Cell Biology,2001 Add to Mendeley ...
Iron Overload in Human Disease Iron is both essential and toxic. The authors review how the body absorbs, uses, and loses iron and explore both common and unusual causes of iron overload and treatment of the resulting disorders. RE Fleming,P Ponka - N Engl J Med 被引量: 0发表: 2012年...
Noun1.iron overload- pathology in which iron accumulates in the tissues; characterized by bronzed skin and enlarged liver and diabetes mellitus and abnormalities of the pancreas and the joints bronzed diabetes,hemochromatosis,iron-storage disease ...
In fact, excess iron can damage cells and tissues, and iron overload is associated with increased risk of cancer and heart disease along with neurological, endocrine, and musculoskeletal disorders (Jellinger 1992; Kew 2009; Shima 1997; Siddique 2012; Huang 2003). Iron is unusual among dietary ...
End stage renal diseaseHemodialysisIron overload is a common complication in patients with chronic renal failure treated with di-alysis prior to the availability of recombinant human erythropoietin therapy. Iron overload was the result of hypoproliferative erythroid marrow function coupled with the need...
Iron overload cardiomyopathy in clinical practice. Circulation 124, 2253–2263 (2011). Article Google Scholar Fleming, R. E. & Ponka, P. Iron overload in human disease. N. Engl. J. Med. 366, 348–359 (2012). Article CAS Google Scholar Powell, L. W., Seckington, R. C. & Deug...
Iron-overload cardiomyopathy is a prevalent cause of heart failure on a world-wide basis and is a major cause of mortality and morbidity in patients with secondary iron-overload and genetic hemochromatosis. We investigated the therapeutic effects of resv
These two fundamental processes are deregulated in hereditary hemochromatosis (HH), leading, over time, to transferrin saturation and iron deposition in parenchymal cells [2]. HH is a highly prevalent iron overload disorder that is, unless recognized and treated, fatal. As the disease progresses, ...
However, the precise mechanisms by which iron overload leads to heart disease are poorly understood. In recent years, significant progress has been made toward understanding the regulatory mechanisms that underlie iron overload in many diseases. In particular, ferroptosis, a newly identified iron-...
As the name suggests, iron overload refers to a state (indeed potentially a disease state) where the total iron content of the body is increased. It is relevant particularly because iron cannot be got rid of without bleeding, or in the last few decades, with chelating agents. Unless it is...