Iron accumulation in the liver causes scarring of the liver (cirrhosis) and an increased risk of developing liver cancer. Hereditary hemochromatosis is an inherited (genetic) disorder in which there is excessive accumulation of iron in the body (iron overload). It is a common genetic disorder ...
However, iron's ability to generate free radicals makes it toxic at high concentrations. For this reason, the body has an intricate regulatory system that ensures iron's availability while also preventing free radical toxicity. Iron overload can develop when mutations occur to the iron regulatory ...
IRON in the bodyMICROPHYSIOLOGICAL systemsCHOROID plexusIRONHOMEOSTASISBLOOD-brain barrierIron overload in many brain regions is a common feature of aging and most neurodegenerative diseases. In this review, the causes, mechanisms, mathematical models, and possible therapies are summarized. ...
Iron Overload in Human Disease Iron is both essential and toxic. The authors review how the body absorbs, uses, and loses iron and explore both common and unusual causes of iron overload and treatment of the resulting disorders. RE Fleming,P Ponka - N Engl J Med 被引量: 0发表: 2012年...
Patients with alcoholic liver disease (ALD) frequently exhibit iron overload but the molecular mechanisms of alcohol and iron interaction are still unclear. This study investigated the role of alcohol in the regulation of iron- responsive genes, hepcidin, hemojuvelin and leap-2 in both dietary and...
Iron Deficiency and Overload In the past seven years numerous genes that influence iron homeostasis have been discovered. Dr. Beutler provides a brief overview of these genes, genes th... Beutler,E. - 《Hematology Am Soc Hematol Educ Program》 被引量: 486发表: 2003年 Overview and mechanisms...
Iron overload ... NS Majhail,HM Lazarus,LJ Burns - 《Bone Marrow Transplant》 被引量: 250发表: 2008年 A Prospective Study of Iron Overload Management in Allogeneic Hematopoietic Cell Transplantation Survivors We report the results of a single-center, prospective evaluation for iron overload and...
iron overload have abnormalliver function teststhat are not obviously related to any other complication of HCT,1312,1317and in some cases these can clinically mimic other conditions (e.g. GVHD).1311,1318Liver biopsyis helpful in these patients, both to confirm the severity of iron overload ...
Define iron maiden. iron maiden synonyms, iron maiden pronunciation, iron maiden translation, English dictionary definition of iron maiden. n. A purported medieval instrument of torture consisting of an iron frame in the form of a person in which the vic
The Magnetic Iron Detector (MID) measures the magnetic track of a person, which depends on the anthropometric characteristics and the body-iron burden. We aim to provide an estimate of this signal in absence of iron overload. We show how this question can be formulated as the estimation of ...