Iron overload, although by no means a new problem, has drawn much more attention over the last few decades. The development of reliable indicative tests of iron status since the early 1970s has sparked a revolution in our understanding of the mechanisms of iron absorption, the processes of ...
this can also create problems. Iron overload is the accumulation of excess iron in body tissues and can cause a disorder called hemochromatosis. This is unlikely to happen from eating foods rich in iron alone. Instead, hemochromatosis is usually caused by either genetic causes or from takingiron...
It is known that common factors can affect both liver iron overload and the risk of cancer, necessitating multivariate analyses of these features in large cohorts of cirrhotic patients. Furthermore, the causes and consequences of hepatic iron overload appear to depend on the cause of the ...
Iron Overload: Consequences, Assessment, and Monitoring. (2012). Iron overload in human disease. N. Engl. J. Med. 366 348–359 10.1056/NEJMra1004967 [ Cross Ref ]Fleming RE, Ponka P: Iron overload ... Taher,Ali,T.,... - 《Hemoglobin》 被引量: 200发表: 2009年 Neonatal hemochromat...
Furthermore, we discuss the pathophysiological mechanisms and consequences of copper deficiency/overload in relation to disease.Cater, Michael A... MA Cater,J Mercer 被引量: 0发表: 2006年 [Pathophysiological mechanisms of formation of iron deficiency states and modern approaches to administration of ...
Summary Iron deficiency is a deficit in total body iron which occurs when the iron requirement, essentially for the production of red blood cells, exceeds the iron supply, with major consequences for human health as well as social and economic development. Iron-deficiency anaemia (IDA) is the ...
At enrollment, all patients were clinically evaluated, and a CMR examination was performed. The CMR parameters determined were those of LV systolic function (EF%) and T2* determination of iron overload in a specific septal region of interest (ROI) (Fig. 2). All image analyses were performed...
Iron metabolism is a tightly regulated physiological process that has relatively low redundancy, and its deregulation often leads to iron deficiency or iron overload. Iron deficiency and iron overload are historically associated with erythroid disorders; however, deregulated iron metabolism is also implica...
Iron overload, notably caused by hereditary hemochromatosis, is an excess storage of iron in various organs that causes tissue damage and may promote tumorigenesis. To manage that disorder, free iron depletion can be induced by iron chelators like defero
Consequences and costs of noncompliance with iron chelation therapy in patients with transfusion-dependent thalassemia: a literature review BACKGROUND: Patients with thalassemia major require iron chelation therapy (ICT) to prevent complications from transfusional iron overload. Deferoxamine is... Thomas,...