Thus, treatment of "iron overload" must depend on the underlying causes, and removal of iron is appropriate in hemochromatosis, but more specific forms of therapy are needed for other forms of iron overload. 1. Ye, H. & Rouault, T. A. (2010). Human iron-sulfur cluster assembly, ...
Hereditary hemochromatosis is aninherited(genetic) disorder in which there is excessive accumulation of iron in the body (iron overload). It is a commongenetic disorderamong Caucasians in the United States, affecting approximately 1 million people in the United States. Individuals affected with heredit...
We generated 3 lines of transgenic mice with graded erythroid overexpression of ERFE and found that they developed dose-dependent iron overload, impaired hepatic BMP signaling, and relative hepcidin deficiency. These findings add to the evidence that ERFE is a mediator of iron overload in ...
Hemolysis impacts overall health because red cells carry the oxygen essential for the survival of every single cell in the body. Secondly, the free hemoglobin released is too much for the liver to break down, which can lead to iron overload and toxicity, affecting multiple organs. Because hemol...
, Newcastle upon Tyne, U.K., said: "Iron overload is bad for the body and needs to be tightly regulated. The genetic study presented at the ESHG today reveals a key role for genes regulating iron metabolism, and also revealed a link between certain types of obesity and iron overload....
Other diseases.People withrheumatoid arthritis, the second most common type of arthritis, are more likely to develop osteoarthritis. In addition, certain rare conditions, such as iron overload or excess growth hormone, increase the chance of developing OA. ...
When someone hastoo muchiron in their blood, this can also create problems. Iron overload is the accumulation of excess iron in body tissues and can cause a disorder calledhemochromatosis. This is unlikely to happen from eating foods rich in iron alone. Instead, hemochromatosis is usually caused...
Other illnesses. People withrheumatoid arthritis, the second most common type of arthritis, are also more likely to get osteoarthritis. People with certain metabolic disorders, such as iron overload or excess growth hormone, also run a higher risk of osteoarthritis. ...
An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in rats and enhancement by iron overload. Carcinogenesis 20, 1801–1808 (1999). CAS PubMed Google Scholar Chisari, F. V. et al. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice. ...
Wilson's disease, an abnormality of copper metabolism Hemochromatosis(iron overload), excess iron buildup Cystic fibrosis Primary sclerosing cholangitis, a hardening of the bile ducts Biliary atresia poorly formed bile ducts Parasite infections such asschistosomiasis ...