iron overloadBackground and Objectives Despite the obligate iron loss from blood donation, some donors present with hyperferritinaemia that can result from a wide range of acute and chronic conditions including hereditary haemochromatosis (HH). The objective of our study was to investigate the ...
Hereditary hemochromatosis is aninherited(genetic) disorder in which there is excessive accumulation of iron in the body (iron overload). It is a commongenetic disorderamong Caucasians in the United States, affecting approximately 1 million people in the United States. Individuals affected with heredit...
We generated 3 lines of transgenic mice with graded erythroid overexpression of ERFE and found that they developed dose-dependent iron overload, impaired hepatic BMP signaling, and relative hepcidin deficiency. These findings add to the evidence that ERFE is a mediator of iron overload in ...
Hemolysis impacts overall health because red cells carry the oxygen essential for the survival of every single cell in the body. Secondly, the free hemoglobin released is too much for the liver to break down, which can lead to iron overload and toxicity, affecting multiple organs. Because hemol...
When someone hastoo muchiron in their blood, this can also create problems. Iron overload is the accumulation of excess iron in body tissues and can cause a disorder calledhemochromatosis. This is unlikely to happen from eating foods rich in iron alone. Instead, hemochromatosis is usually caused...
If the cellulitis is behind the eyeball or in the eye socket, it is orbital cellulitis. Orbital cellulitis is an emergency and can cause permanent loss of vision or spread of infection into the brain (meningitis). This is especially life-threatening in people with diabetes, iron-overload disea...
Other diseases.People withrheumatoid arthritis, the second most common type of arthritis, are more likely to develop osteoarthritis. In addition, certain rare conditions, such as iron overload or excess growth hormone, increase the chance of developing OA. ...
Iron overload Kidney problems Leg ulcers Liver problems Multiple organ failure Another sign-of-the-times complication? Worse outcomes in those with SCA compared to the general population withCOVID-19. Diagnosis How Is Sickle Cell Anemia Diagnosed?
This iron overload can lead to serious health consequences, including painful joints, diabetes, and liver damage, if the iron concentration is not lowered. Hyperkalemia —An abnormally high level of potassium in the blood. Hypernatremia —An abnormally high level of sodium in the blood. ...
Wilson's disease, an abnormality of copper metabolism Hemochromatosis(iron overload), excess iron buildup Cystic fibrosis Primary sclerosing cholangitis, a hardening of the bile ducts Biliary atresia poorly formed bile ducts Parasite infections such asschistosomiasis ...