Activation of Intrinsic Apoptotic Signaling Pathway in A549 Cell by a Pectin Polysaccharide Isolated from Codonopsis pilosula and Its Selenized Derivative[J] . Wenxia Chen,Yuqiang Gou,Wen Li,Pei Zhang,Jiayu Chen,Hongmei Wu,Fangdi Hu,Weidong Cheng.Journal of Carbohydrate Chemistry . 2015 (8)...
W. Johnstone, "Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity," Advances in Cancer Research, vol. 116, pp. 165-197, 2012.Matthews GM, Newbold A, Johnstone RW. Intrinsic and extrinsic apoptotic pathway signaling as deter- min...
One of the reasons for chemotherapy resistance is the failure of tumor cells to go into apoptosis due to defects in the intrinsic apoptotic pathway (e.g., changes in p53). Despite significant improvements in treatment, cure rates for many cancers remain suboptimal. The rise of cytotoxic chemothe...
et al. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc. Natl. Acad. Sci. USA 105, 16677–16682 (2008). Article CAS PubMed PubMed Central Google Scholar Kang, T.B. et al. Caspase-8 serves both apoptotic and nonapoptotic roles. J. Immunol...
For the extrinsic pathway, the binding of ligands to death receptors on the plasma membrane leads to the formation of death-inducing signaling complexes (DISCs) that then go on to signal other apoptotic events. Specifics of the extrinsic mode of apoptosis are covered in Chapter 30. In contrast...
elevated tumour plasticity by altered metastatic behaviour, changes in therapeutic and apoptotic responses, and even in the formation of cancer stem/ initiating cells. While many parts within this multi-step cascade are still poorly understood, this review article predominantly focusses on the ...
Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro- apoptotic stimuli. J Lab Clin Med 2005; 145: 105–110. 16. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti- apoptotic program by HuR. Cell ...
elevated tumour plasticity by altered metastatic behaviour, changes in therapeutic and apoptotic responses, and even in the formation of cancer stem/ initiating cells. While many parts within this multi-step cascade are still poorly understood, this review article predominantly focusses on the ...
Hox-C9 activates the intrinsic pathway of apoptosis. To further analyze Hox-C9-induced cell death, the expression of pro- and antiapoptotic regulators was examined by immuno- blot, qRT-PCR and microarray analysis. Apoptotic cell death was associated with a strong increase of cytochrome c in the...
A. et al. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proc. Natl Acad. Sci. USA 110, 4039–4044 (2013). Article PubMed PubMed Central Google Scholar Luo, X. et al. Enhanced transcriptional activity and mitochondrial localization ...