Furthermore, it was accompanied by an increase in the Bax/Bcl-2 ratio. These results suggest that pulveraven A induces apoptosis in breast cancer cells via the extrinsic apoptotic signaling pathway.doi:10.1038/s41429-021-00435-0Dahae Lee
W. Johnstone, "Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity," Advances in Cancer Research, vol. 116, pp. 165-197, 2012.Matthews GM, Newbold A, Johnstone RW. Intrinsic and extrinsic apoptotic pathway signaling as deter- min...
Apoptosis is known as a physiological process of cell deletion and is also a process of programmed cell death, resulting in morphological change and DNA fragmentation. It is stimulated by external or internal events of cells, one of which is the extrinsic pathway mediated by the death receptor. ...
The intrinsic pathway of apoptosis pathway begins when an injury occurs within the cell and the resulting stress activates the apoptotic pathway. In both the intrinsic and extrinsic pathway of apoptosis, signaling results in the activation of a...
The signaling pathways leading to apoptotic PMN death are classified in two categories: the intrinsic and the extrinsic. In the present study the expressions of proteins participating in the extrinsic apoptotic pathway (DR5, FADD, caspase-8 activity) and the intensity of apoptosis of PMNs from ...
Given that changes in intrinsic apoptosis had limited effects on therapy efficacy, we tested the contribution of the extrinsic apoptotic pathway, which is triggered by binding of death ligands to their cognate receptors and subsequent caspase activation (Fig. S5E). First, we observed that in CHIR...
Vanden Berghe T, van Loo G, Saelens X, Van Gurp M, Brouckaert G, Kalai M, Declercq W, Vandenabeele P (2004) Differential signaling to apoptotic and necrotic cell death by Fas-associated death domain protein FADD. J Biol Chem 279:7925–7933 ...
Apoptotic Cell Death in the Mouse Retinal Ganglion Cell Layer is Induced in vivo by the Excitatory Amino Acid Homocysteine Homocysteine, an excitatory amino acid and a homolog of cysteine, induces neuronal cell death in brain via stimulation of N -methyl- D -aspartate (NMDA) re... P Moore,...
Soluble TNF predominantly acts via TNFR1.15,16 The effects of priming with soluble TNF on Cell Death and Disease TNF and the extrinsic apoptotic pathway in myeloma cells H Rauert et al 4 Figure 2 TNFR1 and TNFR2 activate the classical NFkB pathway in myeloma cells. (a) The indicated cell...
is a common feature of SS, and provide a rationale for targeted therapies to restore the extrinsic Fas-dependent apoptotic pathway in this malignancy.doi... CL Jones,EM Wain,CC Chu,... - 《Journal of Investigative Dermatology》 被引量: 77发表: 2010年 Immune modulation and apoptosis induction...