Intrinsic and extrinsic pathways of apoptosis What is the difference between intrinsic and extrinsic pathway of apoptosis? There are at least two broad signaling pathways that lead to apoptosis: the intrinsic pathway of apoptosis and the extri...
intrinsic pathwaystresstestisTesticular apoptosis is activated by stress, but it is not clear which signaling pathway is activated in response to stress. The aim of this study was to investigate whether intrinsic, extrinsic, or both apoptotic signaling pathways are activated by acute and chronic ...
Harmine is a beta-carboline alkaloid from the plant Peganum harmala. Previous studies found that harmine inhibited metastasis of B16F-10 melanoma cells. This study aims to elucidate the role of harmine in apoptosis of B16F-10 cells. B16F-10 melanoma cell
Collectively, these data suggest that ZEA induced apoptosis and necrosis in rat Sertoli cells via extrinsic and intrinsic apoptotic pathways. This study provides new insights into the molecular mechanisms by which ZEA exhibits cytotoxicity. 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 1731–1739, ...
The signaling pathways leading to apoptotic PMN death are classified in two categories: the intrinsic and the extrinsic. In the present study the expressions of proteins participating in the extrinsic apoptotic pathway (DR5, FADD, caspase-8 activity) and the intensity of apoptosis of PMNs from ...
For the extrinsic pathway, the binding of ligands to death receptors on the plasma membrane leads to the formation of death-inducing signaling complexes (DISCs) that then go on to signal other apoptotic events. Specifics of the extrinsic mode of apoptosis are covered in Chapter 30. In contrast...
that apoptin triggers apoptosis by activating the mitochondrial/intrinsic pathway, and that it acts independently of the death receptor/extrinsic pathway. Jurka... Maddika,S. - 《Journal of Cell Science》 被引量: 223发表: 2005年 Selective Role of Intracellular Chloride in the Regulation of the ...
Novel Role of CHK2 in the intrinsic and Extrinsic Apoptosis Pathway. In response to genotoxic stress, cells activate DNA damage checkpoint pathways that maintain genetic fidelity, promote cell survival, and prevent malignant transformation. Checkpoint kinase 2 (CHK2) is an evolutionarily conserved ...
Apoptosis Inducing Ligand (TRAIL)-induced apoptosis through the regulation of the NFkappaB pathway.;Overall, my work has discovered a novel role of CHK2 in the DNA damage induced intrinsic apoptotic pathway and uncovered its potential role in death receptor mediated extrinsic apoptotic pathway. ...
-9. The initiator caspase-9 then cleaves and activates the executioner caspases-3/6/7, resulting in cell apoptosis. It's totally different from the extracellular signals, which are usually generated by cytotoxic cells of the immune system and trigger apoptosis mainly through the extrinsic pathway....