Mishra R, Emancipator SN, Kern T, Simonson MS. High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells. Kidney Int 67: 82-93, 2005.Mishra R,Emancipator SN,Kern T,et al.High glucose evokes anintrinsic proapoptotics signaling pathway in mesangial cells.Kidney Intn. ...
While we have previously reported the role of tumor necrosis factor-α in extrinsic pathway apoptotic signaling during renal obstruction, to our knowledge its effect on intrinsic pathway signaling and mitochondrial release of cytochrome C has not previously been evaluated. Male Sprague-Dawley rats were...
In the intrinsic pathway, the functional consequence of pro-apoptotic signaling is mitochondrial membrane perturbation and release of cytochrome c in the cytoplasm, where it forms a complex or apoptosome with apoptotic protease activating factor 1 (APAF1) and the inactive form of caspase-9. This co...
Intrinsic apoptosis, the critical programmed cell death pathway that removes excess cells during embryonic development and tissue homeostasis, follows a caspase cascade triggered at mitochondria and modulated by virus-encoded anti-apoptotic B cell leukemia (BCL)2-like suppressors. ...
Collectively, these results indicate that inhibitors for PERK or HSP90, both of which are major proteostatic pathways, modulate chemically induced degradation of BRD4 by affecting different steps of the ubiquitin-proteasome pathway. PDD17273 and GSK2606414 facilitate PROTAC-induced apoptotic cell death ...
The intrinsic pathway of apoptosis pathway begins when an injury occurs within the cell and the resulting stress activates the apoptotic pathway. In both the intrinsic and extrinsic pathway of apoptosis, signaling results in the activation of a fam...
Apoptosis can be triggered via two pathways namely the extrinsic and the mitochon- drial pathway. The extrinsic and mitochondrial apoptotic pathway can be initiated by the caspase-8 and caspase-9, respectively. Both the activation of caspase-8 and cas- pase-9 will lead to the activation of ...
The intrinsic pathway of apoptosis pathway begins when an injury occurs within the cell and the resulting stress activates the apoptotic pathway. In both the intrinsic and extrinsic pathway of apoptosis, signaling results in the activation of a...
Intrinsic and extrin- sic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity. Adv Cancer Res 2012;116(January):165--97.Matthews GM, Newbold A, Johnstone RW. Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor ...
4.1 Intrinsic apoptosis pathway The intrinsic apoptosis pathway is a major RCD mechanism induced by cellular stress, including stress induced by both conventional and targeted anti-cancer therapies [52]. In response to cellular stress, pro-apoptotic proteins BAX and Bcl-2 homologous antagonist/killer ...