Activation of Intrinsic Apoptotic Signaling Pathway in A549 Cell by a Pectin Polysaccharide Isolated from Codonopsis pilosula and Its Selenized Derivative[J] . Wenxia Chen,Yuqiang Gou,Wen Li,Pei Zhang,Jiayu Chen,Hongmei Wu,Fangdi Hu,Weidong Cheng.Journal of Carbohydrate Chemistry . 2015 (8)...
The mitochondrial-mediated intrinsic apoptotic pathway is activated by a mitochondrial derived death signal, leading to the expression of several mitochondrial genes such as bax, bcl-2, p53 and cox-2 resulting in the release of cytochrome c from the mitochondrial inter-membrane space into the ...
Intrinsic and extrinsic apoptotic pathway signaling as deter- minants of histone deacetylase inhibitor antitumor activity. Advances in cancer research. 2012; 116:165-97. doi: 10.1016/B978-0-12-394387-3.00005-7 PMID: 23088871Matthews GM, Newbold A, Johnstone RW (2012) Intrinsic and extrinsic ...
Among these, maybe most strikingly, is the intrinsic apoptotic signaling pathway, which is the conduit by which at least one class of mtROS exercise their actions in the nematodeCaenorhabditis elegans. This is a pathway that normally contributes to organismal homeostasis by killing defective or ...
Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro- apoptotic stimuli. J Lab Clin Med 2005; 145: 105–110. 16. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti- apoptotic program by HuR. Cell ...
In the intrinsic pathway, the functional consequence of pro-apoptotic signaling is mitochondrial membrane perturbation and release of cytochrome c in the cytoplasm, where it forms a complex or apoptosome with apoptotic protease activating factor 1 (APAF1) and the inactive form of caspase-9. This co...
The intrinsic pathway of apoptosis pathway begins when an injury occurs within the cell and the resulting stress activates the apoptotic pathway. In both the intrinsic and extrinsic pathway of apoptosis, signaling results in the activation of a fa...
when conditions in the extracellular environment determine that a cell must die. The intrinsic pathway of apoptosis pathway begins when an injury occurs within the cell and the resulting stress activates the apoptotic pathway. In both the intrins...
Collectively, these results indicate that inhibitors for PERK or HSP90, both of which are major proteostatic pathways, modulate chemically induced degradation of BRD4 by affecting different steps of the ubiquitin-proteasome pathway. PDD17273 and GSK2606414 facilitate PROTAC-induced apoptotic cell death ...
Upregulation of p21 activates the intrinsic apoptotic pathway in β-cells Diabetes manifests from a loss in functional β-cell mass, which is regulated by a dynamic balance of various cellular processes, including β-cell growth,... AM Hernandez,ES Colvin,YC Chen,... - American Journal of ...