The intrinsic apoptotic pathway, also known as the mitochondria-mediated apoptotic pathway, plays important roles in a variety of biological processes and is involved in the pathogenesis of human diseases ranging from immune disorders and neurodegeneration to cancer. Over the last two decades, much ...
Among these, maybe most strikingly, is the intrinsic apoptotic signaling pathway, which is the conduit by which at least one class of mtROS exercise their actions in the nematodeCaenorhabditis elegans. This is a pathway that normally contributes to organismal homeostasis by killing defective or ...
The mitochondrial-mediated intrinsic apoptotic pathway is activated by a mitochondrial derived death signal, leading to the expression of several mitochondrial genes such as bax, bcl-2, p53 and cox-2 resulting in the release of cytochrome c from the mitochondrial inter-membrane space into the ...
Matthews GM, Newbold A, Johnstone RW (2012) Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity. Adv Cancer Res 116: 165-197Matthews GM, Newbold A and Johnstone RW: Intrinsic and extrinsic apoptotic pathway signaling as determinants of...
Prep1(i/i) MEFs also respond faster than WT MEFs to genotoxic stress, indicating increased activation of the intrinsic apoptotic pathways. We did not observe an increase in p53 or an abnormal p53 response to apoptotic stimuli. However, hypomorphic MEFs have decreased endogenous levels of ...
Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro- apoptotic stimuli. J Lab Clin Med 2005; 145: 105–110. 16. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an anti- apoptotic program by HuR. Cell ...
Role of the intrinsic apoptotic pathway incataractogenesis in type 2 diabetic patientsJungY.KimM.S.JooC.K.ChungS.ingentaconnectJournal of Cataract & Refractive SurgeryJung Y, Kim MS,Joo CK, et al. Role of the intrinsic apoptotic pathway in cataractogenesis in type 2 diabetic patients[ J]....
Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to proapoptotic stimuli. J Lab Clin Med 2005; 145: 105–110. 16. Abdelmohsen K, Lal A, Kim HH, Gorospe M. Posttranscriptional orchestration of an antiapoptotic program by HuR. Cell Cycle ...
Manipulation of the Intrinsic Apoptotic Pathway to Enhance Stem Cell Survival Towards an Osteogenic Lineage - Journal of Surgical Researchdoi:10.1016/j.jss.2011.11.517D. LoJ. HyunD. MontoroM. GrovaD.C. WanM.T. LongakerElsevier Inc.Journal of Surgical Research...
1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in cervical cancer cells D. (2014) Inhibition of the nuclear transporter, Kpnbeta1, results in prolonged mitotic arrest and activation of the intrinsic apoptotic pathway in ... Angus,Leaner,D V.,... - ...