We conclude that a pro-apoptotic mechanism centered on the intrinsic (mitochondrial) pathway and regulated by PCAF/ADA3 can influence the progression from premalignant to malignant change, and thus act as a tumor suppression mechanism in gastric cancer....
22]. This intricate complex functions as a master regulator, orchestrating numerous inflammatory signaling pathways [23], akin to its involvement in diseases like rheumatoid arthritis [24,25]. c-Fos is
2.4. miRNA-301a Represses the Apoptotic Pathway via Down-Regulation of the ASK1-Mediated Signaling Pathway during Hypoxia To investigate the signaling molecules that are regulated by miRNA-301a, which target ASK1 under hypoxic conditions, we first examined the ASK1 mRNA and protein expression level...
Some laminins are also regulated by the NF-κB signaling pathway because after activation of the pathway by TNF-α, LAMA5 transcription increased, while the transcription of LAMA4 was unaffected, but the laminin subunits of interest, alpha 1 and beta 1, are not affected in the same fashion ...
在低温条件下, 细胞优先翻译包含特定序列的mRNA分子, 从而调整细胞的蛋白质组成; 低温还诱导蛋白质的磷酸化和乙酰化等翻译后修饰, 使其化学性质发生改变, 更有利于在低温下发挥功能(图2)。基于质谱分析的蛋白质组学技术极大地促进了低温调控的蛋白质及蛋白质翻译后修饰的鉴定。从虾虎鱼(Gillichthys mirabilis)的心脏...
Consistent with this hypothesis, addition of aGalCer to CD1d that is highly expressed on MZB cells. In co-cultures of spleen cells upregulated the expression of apoptotic marker CD95 Tg 2/2 Tg 2/2 Va 14 T cells with B cells from WT or CD1d mice, iNKT (Fas) on MZBs in WT or Va...
We hypothesized that beta-cell stress upregulates p21 to activate the apoptotic pathway and suppress cell survival signaling. To this end, p21 was adenovirally overexpressed in pancreatic rat islets and 832/13 cells. As expected, p21 overexpression resulted in decreased [H-3] thymidine incorporation...
Regulation of the p53 proapoptotic pathway by MYCN and effects of Nut-3.Veronica VeschiMarialaura PetroniBeatrice CardinaliCarlo DominiciIsabella ScrepantiLuigi FratiArmando BartolazziAlberto GulinoGiuseppe Giannini
of GC-induced thymocyte apoptosis, the mitochondrial pathway plays a crucial role, confirmed by the release of CytochromeCand the activation of caspase-9. The activation of caspase-8 was presumably due to cross-talk between apoptotic signaling pathways. We propose that the GC-induced mitochondrial ...
The role of matrix metalloproteinases (MMPs) in endometriosis, a gynecological disease of women, is unclear. The study investigated the activity of MMP-3 and its interplay with MMP-9 during the onset of endometriosis. Additionally, the importance of MMP-3 on the apoptotic pathway in endometriosis...