W. Johnstone, "Intrinsic and extrinsic apoptotic pathway signaling as determinants of histone deacetylase inhibitor antitumor activity," Advances in Cancer Research, vol. 116, pp. 165-197, 2012.Matthews GM, Newbold A, Johnstone RW. Intrinsic and extrinsic apoptotic pathway signaling as deter- min...
The signaling pathways leading to apoptotic PMN death are classified in two categories: the intrinsic and the extrinsic. In the present study the expressions of proteins participating in the extrinsic apoptotic pathway (DR5, FADD, caspase-8 activity) and the intensity of apoptosis of PMNs from ...
The reduction of TUNEL + nuclei number and the incomplete tail regression in our Ci-caspase 8/10 disrupted larvae argue on the implication of an apoptotic pathway regulated by this initiator, potentially extrinsic apoptosis due to the presence of DED prodomain, in accordance with multiple repo...
mice.Conclusions: We provide first evidence for protective effects on the myocardium in a transgenic mouse model of myocardial ischemia-reperfusion due to inhibition of the Bcl-2, but not the FADD pathway despite that reduced apoptotic cells were observed in both groups as compared to wild-type ...
Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-generated reactive oxygen species involvem... LOPES R A;NEVES K B;PESTANA C R;.Testosterone induces apoptosis in vascular smooth muscle cells via extrinsic apoptotic pathway with mitochondria-...
apoptotic pathway in myeloma cells H Rauert et al 6 Cell Death and Disease TNF and the extrinsic apoptotic pathway in myeloma cells H Rauert et al whether TNF-induced upregulation of CD95 was due to the activation of the classical NFkB pathway, we took advantage of the IKK2 inhibitor ...
Tissue inhibitor of metalloproteinases (TIMP)-3, an endogenous inhibitor of MMP-2, which cleaves Fas-L and activates the Fas/Fas-L inducing apoptotic pathway, was increased in Ad-MMP-2-treated cells. Adenovirus-mediated expression of MMP-2 siRNA in human lung xenografts in vivo resulted in ...
Prioritization was carried out for genes of the extrinsic apoptotic signaling pathway considering their role in the structure of the associative genetic network of MDD, since the external pathway of apoptosis is important for drug development. The methods of the ANDSystem, a ...
Prioritization was carried out for genes of the extrinsic apoptotic signaling pathway considering their role in the structure of the associative genetic network of MDD, since the external pathway of apoptosis is important for drug development. The methods of the ANDSystem, a computer system for ...
Furthermore, it was accompanied by an increase in the Bax/Bcl-2 ratio. These results suggest that pulveraven A induces apoptosis in breast cancer cells via the extrinsic apoptotic signaling pathway.doi:10.1038/s41429-021-00435-0Dahae Lee