Kocak H, Ackermann S, Hero B, Kahlert Y, Oberthuer A, Juraeva D, et al. Hox-C9 activates the intrinsic pathway of apoptosis and is associated with sponta- neous regression in neuroblastoma. Cell Death Dis. 2013;4:e586.Kocak H, Ackermann S, Hero B, Kahlert Y, Oberthuer A, Jura...
Intrinsic stresses such as oncogenes, direct DNA damage, hypoxia, and survival factor deprivation, can activate the intrinsic apoptotic pathway. p53 is a sensor of cellular stress and is a critical activator of the intrinsic pathway (See the...
Inoue S, Browne G, Melino G, Cohen GM (2009) Ordering of caspases in cells undergoing apoptosis by the intrinsic pathway. Cell Death Diff 16(7):1053–1061. : 10.1038/cdd.2009.29Inoue S, Browne G, Melino G, Cohen GM. Ordering of caspases in cells undergoing apoptosis by the intrinsic ...
The intrinsic apoptosis pathway, which involves conserved signaling proteins, is physically associated with mitochondria to drive cell apoptosis.
S1). Because caspase 8 is known to initiate the extrinsic apoptotic pathway (4), this finding indicates that the extrinsic pathway is not required for ER stress-induced death. Taken together with the general protection against ER stress-induced apoptosis in caspase 3–/–/caspase 7–/– and ...
[17]. Besides the induction of the extrinsic apoptotic pathway, neutrophils depend on the intrinsic mitochondrial death pathway for execution of Fas-induced apoptosis [i.e., activation of BH3-interacting domain death agonist (BID) and BCL-2-associated X protein (BAX)/BCL-2 homologous antagonist...
Inhibition of the intrinsic apoptosis pathway downstream of caspase 9 activation is a cause for chemotherapy resistance in diffuse large B-cell lymphoma. Clin Cancer Res. In press.Cillessen SA, Hess CJ, Hooijberg E, et al. Inhibi- tion of the intrinsic apoptosis pathway down- stream of ...
Cancer Cell Int (2021) 21:396 https://doi.org/10.1186/s12935-021-02105-5 Cancer Cell International PRIMARY RESEARCH Open Access Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma Chunhui Nie1,2, Bei Wang1...
Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathwayStaurosporine, Apoptosis, Pancreatic carcinoma, Colorectal carcinoma, CancerBackgroundCancer, one of the leading causes of death worldwide, develops when the normal balance between mitosis...
Evidence accumulates that in clinically relevant cell death, both the intrinsic and extrinsic apoptotic pathway synergistically contribute to organ failure. In search for an inhibitor of apoptosis that provides effective blockage of these pathways, we analyzed viral proteins that evolved to protect the ...