The Intrinsic Pathway of Apoptosis. Part I: Apoptosis and Alternative Modes of Cell Death. E D : G e w i r t z D A , H o l t S E a n d G r a n t S . Apoptosis, Senescence, and Cancer. 3 - 3 0 , 2 0 0 7 , H u m a n a Press Inc, Totowa, New Jersey....
Intrinsic stresses such as oncogenes, direct DNA damage, hypoxia, and survival factor deprivation, can activate the intrinsic apoptotic pathway. p53 is a sensor of cellular stress and is a critical activator of the intrinsic pathway (See the p5...
a novel nuclear pathway for apoptosis. Another set of DRs, Apo2 and Apo3, has been characterized that share a different death ligand, known as Apo2L (Apo2 Ligand), Apo3L (Apo3 Ligand). DISC complex formation and BID cleavage downstrea...
Hox-C9 activates the intrinsic pathway of apoptosis. To further analyze Hox-C9-induced cell death, the expression of pro- and antiapoptotic regulators was examined by immuno- blot, qRT-PCR and microarray analysis. Apoptotic cell death was associated with a strong increase of cytochrome c in the...
Pancaspase inhibition had a strong protective effect, whereas flumazenil did not inhibit midazolam-induced apoptosis. Conclusions: Midazolam induces apoptosis via activation of the mitochondrial pathway in a concentration-dependent manner. The mechanism of midazolam toxicity switches from caspase-dependent ...
Nuclear factor-κB (NF-κB) signaling pathway is generally considered as a survival factor that activates expression of various anti-apoptotic genes such as Bcl-2, Bcl-xL that block apoptosis [9]. Inhibition of NF-κB leads to down-regulation of the NF-κB-regulated anti-apoptotic proteins, ...
The second pathway, which is also referred to as the‘intrinsic’pathway, is controlled by members of the Bcl-2 family. A long—stand 二条主要路为apoptosis启蒙存在。 一条路,也被命名`外在’路,由死亡感受器官, TNF感受器官的小群斡旋superfamily。 第二条路,也指`内在’路,由Bcl-2家庭的成员控制...
The intrinsic mitochondrial pathway of apoptosis represents one such promising target for new therapies, and successfully targeting this pathway has the potential to alter the therapeutic landscape of therapy for a variety of cancers. Here, we discuss the biology of the intrinsic pathway of apoptosis,...
The intrinsic apoptosis pathway, which involves conserved signaling proteins, is physically associated with mitochondria to drive cell apoptosis.
17,18,22)—an APAF-1 orthologue that does not require cytochrome c for its assembly into the apoptosome23. The C. elegans apoptosis pathway is also relatively simple, with one pro-survival protein and two BH3-only proteins (EGL-1 and CED-13). By contrast, in humans there are five ...