The Intrinsic Pathway of Apoptosis. Part I: Apoptosis and Alternative Modes of Cell Death. E D : G e w i r t z D A , H o l t S E a n d G r a n t S . Apoptosis, Senescence, and Cancer. 3 - 3 0 , 2 0 0 7 , H u m a n a Press Inc, Totowa, New Jersey....
can activate the intrinsic apoptotic pathway. p53 is a sensor of cellular stress and is a critical activator of the intrinsic pathway (See thep53 Pathway for Apoptosis Signaling). The DNA checkpoints proteins, ATM (Ataxia Telangiectasia Mutated p...
Hox-C9 activates the intrinsic pathway of apoptosis. To further analyze Hox-C9-induced cell death, the expression of pro- and antiapoptotic regulators was examined by immuno- blot, qRT-PCR and microarray analysis. Apoptotic cell death was associated with a strong increase of cytochrome c in the...
aTwo principal pathways for apoptosis initiation exist. One pathway, which is also termed the ‘extrinsic’ pathway, is mediated by death receptors, a subgroup of the TNF receptor superfamily. The second pathway, which is also referred to as the‘intrinsic’pathway, is controlled by members of ...
Intrinsic & Extrinsic pathways of Apoptosis 来自 ResearchGate 喜欢 0 阅读量: 11 作者: NS Al-Ammar 摘要: Is a pathway of cell death in which cells activate enzymes that degrade the cells' own nuclear & cytoplasmic proteins. DOI: 10.13140/RG.2.2.34144.69122 年份: 2016 ...
Nuclear factor-κB (NF-κB) signaling pathway is generally considered as a survival factor that activates expression of various anti-apoptotic genes such as Bcl-2, Bcl-xL that block apoptosis [9]. Inhibition of NF-κB leads to down-regulation of the NF-κB-regulated anti-apoptotic proteins, ...
The intrinsic mitochondrial pathway of apoptosis represents one such promising target for new therapies, and successfully targeting this pathway has the potential to alter the therapeutic landscape of therapy for a variety of cancers. Here, we discuss the biology of the intrinsic pathway of apoptosis,...
The intrinsic apoptosis pathway, which involves conserved signaling proteins, is physically associated with mitochondria to drive cell apoptosis.
In conclusion, our findings reject the hypothesis that theC. elegansprototype for the regulation and execution of the intrinsic apoptosis pathway represents all members of the phylum Nematoda. The important structural differences between both CED-9/BCL-2-like and CED-4/APAF-1-like proteins in spec...
Together, data indicate that prednisolone induces apoptosis in corneal epithelial cells through GR and the intrinsic pathway involving mtROS, caspase-9, and -3. The pro-apoptotic effects of glucocorticoids along with their anti-inflammatory effects should be considered when glucocorticoid eye drops are...