Induction with etoposide resulted in caspase-9 mediated apoptosis in EATL cells with relatively high Noxa expression, whereas in EATL cells with low Noxa expression no apoptosis was induced, suggesting an inhib
We studied fetal germ-cell fates and discovered that both apoptosis and differentiation initiate in clonally related clusters. Lineage tracing confirmed that germ cells die as clones independent of intercellular bridges, suggesting that shared intrinsic properties are apoptotic determinants. We identified ...
While the activated p53 promotes cell cycle arrest and DNA repair, it also drives the intrinsic and extrinsic apoptosis pathway by the upregulation of pro-apoptosis factors3. Since p53 was not fully activated in resting CD4+ T cells (Fig. 3g), we speculated that p53-independent pathways might...
For example, the glycoprotein-120 (gp-120), exposed on the envelope of an HIV particle was shown to activate the mitochondrial caspase pathway in the axon, which caused local damage to the nerve. Furthermore, gp-120 was shown to induce neuronal apoptosis in a Schwann cell-dependent manner ...
A number of studies have suggested a role for estrogen in the regulation of DNA repair activity. Furthermore, mutations or epigenetic silencing in DNA repair genes have been associated with the sensitivity of cancers to hormonal therapy. The molecular basis for the progression of cancers from ...
Although cancer cells appear to maintain the machinery for intrinsic apoptosis, defects in the pathway develop during malignant transformation, preventing apoptosis from occurring. How to specifically induce apoptosis in cancer cells remains unclear. We determined the apoptosome activity and p53 status of...
Apoptosis is a fundamental process for the elimination of damaged or unwanted cells, and is a key aspect of development. It is triggered by pro-apoptotic genes responding to the intrinsic pathway that senses cell stress or the extrinsic pathway that responds to signals from other cells. The ...
To date, the checkpoint factors acting downstream of CHK2/p53/p63 to trigger oocyte apoptosis have not been identified. The p53 and p63 transcription factors bind many genomic sites and regulate multiple cellular responses20. Among their mitotic targets are intrinsic apoptosis pathway components PUMA,...
Given that the variable region of the BCR in PAPS patients show lower diversity compared to controls, we explored the hypothesis that a restricted repertoire encoding the variable regions of heavy and light chain and/or intrinsic BCR features may explain a predetermined reactivity of aPL B cells....
Scripts used for repli-ATAC-seq analyses, related to STAR Methods Table S1. List of gene sets that were used to calculate expression differences in transcription based on scVASA-seq dataset, related to Figure 3 Table S2. SILAC-MS on histone variants and their PTMs, related to Figure 4 ...