One of the two archetypal pathways of caspase activation, known also as "the death receptor pathway." This pathway of programmed cell death is initiated through the stimulation of the transmembrane...Springer Berlin HeidelbergEncyclopedia of Cancer...
What is the difference between intrinsic and extrinsic pathway of apoptosis? There are at least two broad signaling pathways that lead to apoptosis: the intrinsic pathway of apoptosis and the extrinsic pathway of apoptosis. The extrinsic pathway...
In molecular biology, the words extrinsic pathway may refer to both the extrinsic pathway of apoptosis and the extrinsic pathway of blood coagulation. Here we mainly talk about the first kind of extrinsic pathway which is extrinsic apoptosis pathway. Extrinsic apoptosis pathway is one of the signal...
Apoptosis is controlled by the extrinsic death receptor pathway and the intrinsic mitochondrial pathway. Notably, both pathways converge at caspase-3, leading to activation of other proteases. Caspases have more than 400 different substrates that interfere with transcription, translation, DNA cleavage, cy...
Related to extrinsic pathway:Prothrombin time,APTT extrinsic pathway Hematology The arm of coagulation activation which, like the intrinsic pathway, converges on the common pathway, ie factor X activation; the EP is activated by exposure of blood to tissue factor, circulating factor VII, Ca2+ and ...
A cell starts programmed cell death when DNA damage occurs, thereby activating the intrinsic pathway of apoptosis or when the extrinsic pathway is activated by external signals, such as the Fas ligand (FasL) or TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) (Wang, 2001). Effects...
Song J,Joshi RP,Beebe SJ.Cellular apoptosis by nanosecond, high-intensity electric pulses:model evaluation of the pulsing threshold and extrinsic pathway. Bioelectrochemistry . 2010Song J, Joshi RP, Beebe SJ: Cellular apoptosis by nanosecond, high-intensity electric pulses: model evaluation of the ...
Overall, these results reveal a TRF2-dependent pathway that is tumour-cell extrinsic and regulates NK cell immunity. This is a preview of subscription content, access via your institution Access options Access through your institution Subscription info for Chinese customers We have a dedicated web...
Exposure of BJAB cells to [YR(mtbmp)(thf)] led to a death receptor-mediated reduction of cell viability and induction of apoptosis. The independence of Bcl-2 expression supports the suggestion that the [YR(mtbmp)(thf)]-induced apoptosis is mainly mediated via the extrinsic pathway. The ...
withinneuronandneuronalapoptosishasbeenestablished.WereportthatexpressionofCHPVphosphoproteinincreasesupto6hpostinfectionanddiminishesthereafterinneuronalcelllines,signifyingthereplicativephaseofCHPV.VariousanalysesconductedduringtheinvestigationestablishedthatCHPV-infectedneuronsareundergoingapoptosisthroughanextrinsicpathway...