Assuming you are sampling a large population with no natural selection or mutations and the SNP resides on an autosomal chromosome, SNP genotyping data should follow the Hardy-Weinberg equilibrium, a distribution equation that ...
34. Genome-wide mosaicism, chimerism, and contamination: Recognizing and interpreting genotyping patterns from SNP arraysdoi:10.1016/j.cancergen.2018.04.095Conlin Laura K.Luo MinjieWeckselblatt BrookeRafferty Kelly A.Kalish JenniferZackai Elaine H....
In Chapter 1, we provide an overview of the bioinformatics challenges associated with the analysis of data from large genotyping arrays. In Chapter 2, we use a machine learning algorithm combined with SNP filtering methods and traditional statistics to identify SNP-SNP interactions that are highly ...