GENE expressionFinding meaning in the myriad genetic associations identified between SNPs and traits is a daunting challenge, and identifying functions for SNPs that lie outside protein-coding regions presents particular difficulties. In a recent study, Visser et al....
In contrast, the genes BTB-POZ and PCN showed no significant difference in the relative expression levels. The genotypes ZZ1 did not show a significant difference in the relative gene expression level of genes ARK and NB-ARC compared with control when subjected to inoculation treatment. However,...
Promoter SNPs: These SNPs reside within the promoter region of a gene, impacting the initiation of transcription and thereby influencing gene expression levels. Intron SNPs: Intron SNPs are situated within the non-coding regions (introns) of a gene and can influence mRNA splicing or other regulator...
摘要: Discusses the single nucleotide polymorphisms (SNP) and disease-susceptibility genes in digestive organ diseases. Use of SNP as DNA markers for population genetics; Genotypic risks associated with variants of SNP.关键词: gene expression chemosensitivity 5-fluorouracil cisplatin ...
Three QTLs associated with low-temperature tolerance were identified by genome-wide association analysis, and 15 candidate genes were identified by haplotype analysis and gene expression analyses. Abstract Low temperature is a critical factor affecting the geographical distribution, growth, development, and...
gene expression levels of HapMap CEU lymphoblastoid cell lines were assessed by using Affymetrix GeneChip Human Exon 1.0 ST array. Finally, Duan and coworkers created an eQTL resource containing the pairwise association between 12,747 gene expression levels and 2,098,437 SNPs in the HapMap CEU ...
We searched the genome browser to find the corresponding susceptibility genes and used the GTEx database to confirm the regulation of gene expression. A polygenic risk score approach was also applied to evaluate the genetic variants in the prediction of developing AS. Results The results showed ...
Desmoglein 4 is a novel gene involved in hair growth This invention provides methods and compositions for inhibiting the expression of desmoglein 4. This invention also provides pharmaceutical compositions for inhibiting hair growth in a subject. AM Christiano - US 被引量: 415发表: 2004年 Mutations...
Identification and validation of regulatory SNPs that modulate transcription factor chromatin binding and gene expression in prostate cancer Oncotarget (2016) Google Scholar [16] R. Karchin, M. Diekhans, L. Kelly, D.J. Thomas, U. Pieper, N. Eswar, et al. LS-SNP: large-scale annotation of...
pathway genes and provide reliable support for clinical treatment regimens. Meanwhile, in order to validate the effect of these variant on gene expression, we performed an expression quantitative trait loci (eQTLs) analysis using three large-scale expression datasets....