Wolf G, Livshits D, Beilin B, Yirmiya R, Shavit Y. Interleukin-1 signaling is required for induction and maintenance of postoperative incisional pain: genetic and pharmaco- logical studies in mice. Brain Behav Immun 2008;22(7):1072-7 Epub 2008 Apr 28....
11 However, the role of IL-1 signaling in TKI resistance of CML LSC is not known, and it is not known whether inhibiting IL-1 signaling could enhance elimination of CML LSC. IL-1 receptor antagonist (IL-1RA) is a member of the IL-1 cytokine family that binds nonproductively to IL-1...
Interleukin-1 signaling in mouse astrocytes involves Akt: a study with interleukin-4 and interleukin-10 来自 Semantic Scholar 喜欢 0 阅读量: 26 作者:F Pousset,R Dantzer,KW Kelley,P Parnet 展开 摘要: Although astrocytes are well known to respond to the pro-inflammatory cytokine, interleukin-...
An immunopathogenic perspective of interleukin-1 signalingdoi:10.1038/s41423-020-0475-yXinwen LinTrix TwelkmeyerSi-Yu WangRuo-Nan XuHong TangCellular & molecular immunology
IL-1 (interleukin 1) receptor belongs to the Toll-IL-1-receptor (TIR) superfamily, which is defined by an intracellular TIR domain that initiates the signaling cascade. TIR receptors can be divided into 2 subgroups regarding the extracellular domains. One group contains a leucine-rich repeat mot...
3.Brikos C, Wait R, Begum S, O'Neill LA, Saklatvala J. Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol Cell Proteomics. 2007 Sep;6(9...
近日,一篇发表在国际杂志Brain, Behavior, and Immunity上题为“Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice”的研究报告中,来自Scripps研究所等机构的科学家们通过研究揭开了免疫系统在上述恶性循环中所扮演的...
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30, 576–587 (2009). Article CAS PubMed PubMed Central Google Scholar Acosta-Rodriguez, E. V. et al. Interleukin 1β and 6 but not transforming growth factor-β are essential for the differentiation ...
Inflammatory cytokines regulate endothelial cell survival and tissue repair functions via NF-κB signaling RNA interference targeting nuclear factor (NF)- ampkappaB p blocked the effects of IL-ampszlig or TNF-ampalpha on cell morphologic change, survival, ... Kanaji,N,Sato,... - 《Journal of...
However, the significance of many of these signaling events is unclear, due to the use of different and sometimes unique cell lines in studying IL-1-initiated signal transduction. Complicating matters further is the lack of association in many studies between identified IL-1-induced signals and ...