- Interleukin-1 signaling is requi- red for induction and maintenance of postoperative incisional pain: genetic and pharmacological studies in mice. Brain Behav Immun, 2008;22:1072-1077.Wolf G, Livshits D, Beilin B, Yirmiya R, Shavit Y. Interleukin-1 signaling is required for induction and...
Nearly every known signal transduction pathway has been reported to be activated in response to IL-1. However, the significance of many of these signaling events is unclear, due to the use of different and sometimes unique cell lines in studying IL-1-initiated signal transduction. Complicating ...
An immunopathogenic perspective of interleukin-1 signalingdoi:10.1038/s41423-020-0475-yXinwen LinTrix TwelkmeyerSi-Yu WangRuo-Nan XuHong TangCellular & molecular immunology
Although astrocytes are well known to respond to the pro-inflammatory cytokine, interleukin-1 (IL-1), the receptor and post-receptor mechanisms that mediate IL-1 effects in this cell type are complex and need further investigation. Using electrophoretic mobility shift assay (EMSA), we show that...
IL-1 signaling has roles in β-cell dysfunction and destruction via the NFκB and mitogen-activated-protein-kinase pathways, leading to endoplasmic reticulum and mitochondrial stress and eventually activating the apoptotic machinery. In addition, IL-1 acts on T-lymphocyte regulation. The modulating ...
IL-1 (interleukin 1) receptor belongs to the Toll-IL-1-receptor (TIR) superfamily, which is defined by an intracellular TIR domain that initiates the signaling cascade. TIR receptors can be divided into 2 subgroups regarding the extracellular domains. One group contains a leucine-rich repeat mot...
Interleukins are a group of cytokines (secreted proteins and signaling molecules) that were first seen to be expressed by white blood cells (leukocytes).
3.Brikos C, Wait R, Begum S, O'Neill LA, Saklatvala J. Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding identifies IL-1RAcP, MyD88, and IRAK-4 as the stable components. Mol Cell Proteomics. 2007 Sep;6(9...
tumorigenesis, we investigated whether the HIF-1 signaling pathway was stimulated by the pro-inflammatory cytokine interleukin-1beta (IL-1beta) in A549 ... Yun-Jin Jung,JS Isaacs,S Lee,... - 《Faseb Journal》 被引量: 1293发表: 2003年 The secretory route of the leaderless protein interleuki...
signaling (Caër et al., 2017). Furthermore, in women suffering from PCOS, the increased IL-1β concentration exacerbates reproductive dysfunction (Xia et al., 2013) and inhibits embryo implantation by suppressing progesterone (Wang et al., 2002). Low level of IL-1β were shown to ...