IL-1 familyIL-1 gene polymorphismsMode of actionType 2 DiabetesCytokines are small cell signaling protein molecules which encompass a large and diverse family. They consist of immunomodulating agents such as interleukins and inteferons. Virtually all nucleated cells, especially endo/epithelial cells ...
The interleukin (IL)-l extended family (IL-lFx) of beta trefoil cytokines now includes a total of 11 members, many of which have been identified as being produced by dendritic cells (DC)s and acting on natural killer (NK) and T-cells. Their major role in immunity remains not fully ...
IL-1 (interleukin 1) receptor belongs to the Toll-IL-1-receptor (TIR) superfamily, which is defined by an intracellular TIR domain that initiates the signaling cascade. TIR receptors can be divided into 2 subgroups regarding the extracellular domains. One group contains a leucine-rich repeat mot...
Interleukin-1 Receptor and Toll-Like Receptor Signaling The Toll-like receptor (TLR) family, consisting of 10 human members, recognize pathogen-associated molecular patterns, such as LPS and flagellin, and are components of the innate immune system. The interleukin-1 receptor (IL-1R) family recogn...
Interleukin-1 (IL-1) Receptor-Associated Kinase Leads to Activation of TAK1 by Inducing TAB2 Translocation in the IL-1 Signaling Pathway Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol. Cell. ......
TNF–α is a protein-based molecule, synthesized by monocytes/macrophages in response to inflammatory signaling and has a wide variety of cellular effects upon binding to its receptor, i.e., TNFR-1 and 2 receptors (Idriss and Naismith, 2000). It regulates immune responses by controlling apoptos...
Investigators have studied how production of the different members of the IL-1 family is controlled, the various biological activities of IL-1, the distinct and various functions of the IL-1 receptor (IL-1R) family and the complexity of intracellular signaling. Mice deficient in IL-1, IL-1 ...
2.Dinarello CA. The interleukin-1 family: 10 years of discovery. FASEB J. 1994 Dec;8(15):1314-25. 3.Brikos C, Wait R, Begum S, O'Neill LA, Saklatvala J. Mass spectrometric analysis of the endogenous type I interleukin-1 (IL-1) receptor signaling complex formed after IL-1 binding...
The IL-1 family of cytokines and receptors in rheumatic diseases Article 12 September 2019 IL-17 receptor–based signaling and implications for disease Article 19 November 2019 Shared inflammatory pathways of rheumatoid arthritis and atherosclerotic cardiovascular disease Article 25 May 2023 Refere...
These studies provide further evidence for the role of reduced interleukin-1α signaling in the decline of permeability barrier function in aged skin, and point to the potential use of cytokine augmentation in barrier dysfunction of the aged. 展开 关键词: epidermis aging interleukin-1 imiquimod ...