The family members are known to play an essential role in inflammation. The importance of inflammation in cancer has been well established in the past decades. This review sets out to give an overview of the role of each IL-1 family member in cancer pathogenesis and show their potential as ...
IL-1 belongs to a family of ligands and receptors.7 The classic members IL-1α and IL-1β mediate their biological responses via activation of the IL-1 receptor type I, which is expressed by almost all cell types. The IL-1 receptor antagonist (IL-1Ra), the third member of the IL-1...
IL-1 (interleukin 1) is the first member of the IL-1 family which is closely linked to the innate immune response. IL-1 affects virtually all cells and organs and is a major pathogenic mediator of autoinflammatory, autoimmune, infectious, and degenerative diseases. ...
ST2 is a member of the interleukin-1 receptor family and has 2 isoforms that are directly implicated in progression of cardiac disease: soluble ST2 (sST2) and a transmembrane-bound form, ST2 ligand (ST2L). IL-33 is the hormone that interacts with ST2L, protecting against left ventricular h...
When analyzing cytokine levels for the ER (-) versus ER (+) patient groups, we found that in many instances these groups showed a different cytokine profile. These studies suggest that the IL-1 family of cytokines may be important in regulating protumorigenic activities within the HBC tumor ...
背景 Interleukin-1 alpha (IL1α) is a cytokine member of the interleukin-1 family. IL-1 consists of two distinct forms: IL1α and IL1β that recognize the same cell surface receptors but are distinct proteins with approximay 25% amino acid sequence identity. IL1α is constitutively produc...
IL1-B; IL1-Beta; IL1F2; IL-1β; Interleukin-1 Family Member 2; CatabolinCCC A563 HGNC 5992 MGI 96543 PubMed 19431193 RGD 2891 UniProt P01584 Wiki IL1B Interleukin-1 (IL-1) is one of the first cytokines ever described. Its initial discovery was as a factor that could induce ...
ST2 (growth STimulation expressed gene 2; also known as IL1RL1, or Interleukin-1 ReceptorLike 1) is a member of the interleukin-1 receptor family. The ST2 protein has two isoforms directly implicated in the progression of cardiac disease: soluble ST2 and a cell membranebound isoform, ST2L....
IL1A is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which
is a member of the IL-1 family, and like , proIL-18 is cleaved by ICE to yield an active molecule. However, unlike , is not an endogenous pyrogen following intraperitoneal injection into . Nevertheless, may contribute to inflammation and fever because is a potent inducer of , chemokines, ...