白细胞介素家17族(Interleukin 17 family,IL-17家族),是与白细胞介素17(Interleukin 17,IL-17)具有较高同源性、在脊椎动物进化中高度保守的一组蛋白质,目前共有六个成员,IL-17A(原IL-17)、B、C、D、E和F[1]。其中,IL-17B、C、D、E、F的编码基因,是在人类基因组大规模测序过程中,通过同源性分析、EST...
As potent pro-inflammatory mediators, cytokines in the interleukin-17 (IL-17) family play crucial roles in inflammation, autoimmunity, and host defense. In the past decade, substantial progress was made in the identification of IL-17-producing cell subsets as well as the new functions of IL-...
参考文献: 1. The IL-17 Family of Cytokines in Health and Disease. Immunity. 2019 Apr 16;50(4):892-906. 2. IL-17 Signaling:The Yin and the Yang. Trends Immunol. 2017 May;38(5):310–322.
any of a family of small proteins that participate in the body's defense system, esp. by promoting the growth and activation of white blood cells. [1979;inter- +leuk(ocyte) +-in1; so called because such proteins act as agents of communication between different populations of leukocytes] ...
Functional specialization of interleukin-17 family members. Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17... Y Iwakura,H Ishigame,S Saijo,... - 《Immunity》 被引量: 1643发表...
, 12Although the proinflammatory function and intracellular signaling pathway of IL-17 is strikingly similar to those of IL-1 and Toll receptors, IL-17R has no homology with other known receptor sequences, thus making IL-17, homologous proteins, and its viral homologue a novel cytokine family....
Functional specialization of interleukin-17 family members. Immunity 2011; 34: 149–162. CAS PubMed Google Scholar Gerhardt S, Abbott WM, Hargreaves D, Pauptit RA, Davies RA, Needham MR et al. Structure of IL-17A in complex with a potent, fully human neutralizing antibody. J Mol Biol ...
编 号包装库存目录价(￥)您的价格(￥)数量 C630014-00055 UG现货630630 产品描述 概述 Human Interleukin-17A (IL-17A) is encoded by the IL17A gene located on the chromosome 6 and belongs to the IL-17 family that contains IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. They have...
In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, the IL-17 family has widespread expression throughout evolution, dating as far back as cnidaria, molluscs and worms, which predate lymphocytes. The evolut
Interleukin-17A (IL-17A) is the signature cytokine of the recently identified T helper 17 (Th17) cell subset. IL-17 has six family members (IL-17A to IL-17F). Although IL-17A and IL-17F share the highest amino acid sequence homology, they perform distinct functions; IL...