摘要: This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.收藏 引用 批量引用 报错 分享 文库来源 其他来源 求助全文 Fatty acid synthetase inhibiter 优质文献 相似文献The method of obstructing the occurrence of the cancer by the fatty acid synthetase inhibit...
Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-in... Activity and expression of fatty acid synthase (FAS), a critical enzyme in the de novo biosynthesis of fatty acids in mammals, is exquisitely...
Fatty acid synthase (FASN) is a crucial enzyme involved in lipid metabolism that catalyzes the final steps of de novo fatty acids [11]. Upregulation of FASN is associated with the progression of several cancers, including prostate [12], ovarian [13], breast [14], liver [15] and cervical...
Prostate cancer cells require high rates of de novo fatty acid synthesis and protein synthesis for their rapid growth. We report here that the growth of these cells is markedly diminished by incubation with activators of AMP-activated protein kinase (AMPK), a fuel-sensing enzyme that has been ...
摘要：Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including those mediated by inhibition of fatty acid synthase (FASN) enzyme, such as, cancer, obesity or related disorders, and liver related disorders. Such compounds are ...
It was recently confirmed in several studies that phosphorylation of Ser1177 in human ecNOS (Ser1179 in bovine ecNOS) leads to ecNOS activation and enhances the ability of the enzyme to generate NO in endothelial cells. One compensatory mechanism is that γ-tocopherol can be nitrated and thus ...
Furthermore, CGDCM and DOX therapy decreased ATP and fatty acid synthesis in rat liver cancer, which was correlated with apoptosis inhibition. CGDCM reduced cleaved caspase-3 expression in liver cancer rats when used alone or in combination with DOX, implying that apoptosis-inducing hepatic ...
LDH is a tetrameric enzyme comprised of two major subunits A and/or B, resulting in five isozymes that can catalyze the inter-conversion of pyruvate and lactate. LDHA and LDHB proteins are differentially regulated in cancer cells. LDHB, when present, is constitutively expressed, whereas LDHA is...
2.6. Enzyme-linked immunosorbent assay (ELISA) Supernatants acquired from the aforementioned protocols were utilized to elucidate the activities of adenylyl cyclase (AC) and cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) and cAMP levels in B16F10 cells with the help of ELISA...
The cells were then homogenized using a Teflon pestle tissue homogenizer on ice. The samples were centrifuged at 1,008g for 5 min and the supernatant was stored at 4 °C until enzyme analysis. Each sample and a blank were reacted with the cocktail [1 mM of 1-chloro-2,4-dinitrobenzene...