One of the important techniques for development of three-dimensional (3D) in vitro model is 3D bioprinting, which makes realistic in vitro disease models and mimics the actual cellular arrangement of any human tissue or organ. Organ-on-a-chip as 3D in vitro model has shown its potential to ...
The occurrence of idiosyncratic drug hepatotoxicity is a major problem in all phases of clinical drug development and the most frequent cause of post-marke... Kaplowitz,Neil - 《Nature Reviews Drug Discovery》 被引量: 1660发表: 2005年 Reconstituting Organ-Level Lung Functions on a Chip Here, ...
Such immune models can enhance the performance of novel drug candidates during clinical trials and contribute to reducing the high attrition rate as well as the high cost associated with drug development. 展开 关键词: drug development, drug discovery, immune system, in vitro, organ-on-chip, ...
Calcium carbonate nanoparticles stimulate cancer cell reprogramming to suppress tumor growth and invasion in an organ-on-a-chip system Article Open access 29 April 2021 A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+ breast cancer cells Art...
extracellular matrix 3D models tumor on a chip Towards Biologically Relevant Tumor Models The composition of the tumor microenvironment (TME, see Glossary) and tumor stromal interactions are major factors that aggravate tumor growth and metastasis, leading to poor clinical outcomes [1., 2., 3., 4...
3. Cancer niche-on-chip Advances in Organ-on-chip platforms have led to use this approach to construct in vitro 3D tumor models, providing new avenues for oncology research. The Tumor-on-chip has become a prospect in cancer biology research, understanding the mechanisms of tumor evolution (sim...
How Do Organ-On-Chip Devices Work? Organ-on-chip devices work by recreating the microenvironment of specific human organs in vitro. They typically consist of two primary components: the microfluidic chip and the living cells. The chip is designed to provide a 3D scaffold for the cells, allowin...
Also, intestinal villi and secretory mucus present functionally differentiated epithelial cells with a protective barrier at the intestinal mucosal surface. Thus, re-creating the 3D epithelial structure is critical to building in vitro intestine models. Notably, an organomimetic gut-on-a-chip can ...
Recent advances in three-dimensional (3D) cell culture models developed on organ-on-a-chip or microfluidic devices have shown their capability to recapitulate the in vivo microenvironment as well as their potential as tools in biomedical research. Here, we present an in vitro model of the periphe...
Brain development is an extraordinarily complex process achieved through the spatially and temporally regulated release of key patterning factors. In vitro neurodevelopmental models seek to mimic these processes to recapitulate the steps of tissue fate a