In this chapter, we emphasize on the development of superior yeast strains for the production of bioethanol from lignocellulosic biomass. For instance, the substitution of a threonine at the position of 255 to alanine in ubiquitin ligase Rsp5 could increase the resistance of Saccharomyces cerevisiae ...
It is well known that E-cadherin is internalized by endocytosis when p120 dissociates from the juxtamembrane domain of E-cad- herin and ubiquitin ligase Hakai is a key factor in the demise of p120- deprived E-cadherin.29,30,33 Therefore, we investigated whether loss of p120 association with...
(2021). E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability. Cell Death & Disease, 12(3), 239. Article CAS Google Scholar Man, X., et al. (2019). USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in ...
Protein stability is controlled by the formation of polyubiquitin chains on proteins, which target them for degradation by the proteasome. Ubiquitylation can be catalysed by HECT-E3 ligases that transfer ubiquitin (Ub) from a conserved Cys residue in the catalytic HECT domain onto target proteins, ...
Proteolysis-targeting chimeras (PROTACs) are a class of bifunctional molecules that can induce the ubiquitin degradation of its target protein by hijacking the E3 ligase to form a target protein-PROTAC-E3 ligase ternary complex. Its underlying principle has inspired the development of a wide range ...
The APC/C Ubiquitin Ligase: From Cell Biology to Tumorigenesis In this review we will discuss the importance of APC/C to normal cell proliferation and development, thus underscoring its possible contribution to ... P Clara,R Vimal,AN George - 《Frontiers in Oncology》 被引量: 35发表: 2012年...
On the one hand, studies using ectopic expression of nuclear localization signal (NLS) and nuclear export signal (NES) mutants of p53 and MDM2, the main E3 ubiquitin ligase of p53, have suggested that relocalization to the cytoplasm is necessary for efficient p53 degradation. On the other hand...
parkin plays an important role in mitochondrial functioning, as well as the ubiquitin proteasome system, where it acts as a ubiquitin e3 ligase. impaired autophagy and mitophagy, protein accumulation, and mitochondrial dysfunction are the main mechanisms proposed in the development of parkinsonism due ...
It is thought that decreased p27 expression in tumors is caused by increased proteasomal turnover, in particular activation of the pathway governed by the SCFskp2 E3 ubiquitin protein ligase. We have directly tested the importance of the SCFskp-mediated degradation of p27 in tumorigenesis by ...
Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling. Mol. Cell. 2009, 36, 457–468. [CrossRef] [PubMed] 29. Yumoto, K.; Thomas, P.S.; Lane, J.; Matsuzaki, K.; Inagaki, M.; Ninomiya-Tsuji, J.; Scott, G.J.; Ray, M.K.; Ishii, M.; Maxson, R...