Summary Core transcription factor (TF) IIH purified from yeast possesses an E3 ubiquitin (Ub) ligase activity, which resides, at least in part, in a RING finger (RNF) domain of the Ssl1 subunit. Yeast strains mutated in the Ssl1 RNF domain are sensitive to ultraviolet (UV) light and ...
regulation of ubiquitin-protein ligase activity 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 泛素蛋白连接酶的活性的调控...
Mutations in the gene encoding the E3 ubiquitin ligase TRIAD3A cause adult-onset neurodegenerative disorders. We reveal that the ubiquitin ligase activity of TRIAD3A promotes its liquid–liquid phase separation. TRIAD3A co-partitions with tau into droplets, where tau forms fibrillar aggregates. TRIAD...
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP Hyper-phosphorylated tau accumulates in Alzheimer’s disease; but the roles of these phosphorylation sites are unclear. Here the authors show that phosphorylation of a single site, pSer416, limits its tur...
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1 G Levkowitz,H Waterman,SA Ettenberg,... 被引量: 0发表: 1999年 Insulin-Dependent Diabetes Affects Testicular Function by FSH- and LH-Linked Mechanisms c-kit, insulin-like growth ...
M. (2003). Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science, 300(5617), 342–344. https://doi.org/10.1126/science.1080386 Article CAS PubMed Google Scholar Gu, B., & Zhu, W. G. (2012). Surf the post-translational modification network of p53 regulation. ...
We found that Parkin has E3 ubiquitin ligase activity in this system, demonstrating for the first time that the E3 activity is an intrinsic function of the Parkin protein and does not require posttranslational modification or association with cellular proteins other than an E2 (human Ubc4 E2 was...
This protein was demonstrated to have ubiquitin ligase activity in vitro [26]. PHD motifs have more recently been identified in several viral and human proteins playing key roles as E3s in the downregulation of cell-surface proteins (reviewed in Ref. [14]). A key issue in the ubiquitin ...
摘要: Disclosed are purified nucleic acid molecules encoding polypeptides having ubiquitin ligase activity and the ability to bind XA21. Also disclosed are methods of making disease-resistant plants and methods or screening compounds for the ability to enhance a disease-resistant phenotype in plants.收藏...
is negatively regulated by the ubiquitin ligase RPM-1. RPM-1 ubiquitin ligase activity restricts UNC-51 and autophagosome formation within specific axonal compartments, and exerts effects broadly across the nervous system. By restraining UNC-51 activity, RPM-1 inhibits autophagosome formation to affect...