This article aimed to provide a review on the role of ubiquitination and de-ubiquitination, especially ubiquitin ligase enzymes and de-ubiquitinating enzymes, in the above four pathways. We hope that our work can contribute to the research and development of treatment strategies for innate immunity...
The E3 ubiquitin ligases cooperate with E2 ubiquitin conjugating enzymes to assemble multi-ubiquitin chains on substrate proteins. Generally, ubiquitin ligases, whether monomeric, or multimeric complexes, contain domains that recognize substrate proteins specifically, as well as domains that interact with E2...
A key class of enzymes called ubiquitin ligases, which has been shown to play a crucial role in the ubiquitination process, can positively or negatively regulate T cell responses. This review summarizes the recent advances defining the roles of several ubiquitin ligases in T cell activation and ...
E3 enzymes involve in substrate recognition and ubiquitin transfer to a single, multiple Lys (mono-/multi-ubiquitination) or as a poly-Ub chain (poly-ubiquitination) residues of the substrate (HECT family) [5] or easing ubiquitin transfer from E2 to the target protein (RING family). All ...
In the last step, a member of a highly diverse class of enzymes known as ubiquitin ligases (E3) recognizes the specific protein to be ubiquitinated and catalyzes the transfer of ubiquitin from E2 to this target protein. 最后,高度保守的泛素连接酶 (E3)家族中的一员(根据底物蛋白质的不同而不...
In addition, the RING/PH domain structure found in Ste5p is characteristic of the RING class of ubiquitin-ligating enzymes =-=(18)-=-, suggesting that Ste5p could play a role in the proteolytic stability of the mating response pathway components. In addition to Ste5p, the yeast S. ...
Really interesting new gene (RING) domains coordinate zinc ions and often mediate binding of E2 ubiquitin conjugating enzymes. HECT domain Homologous to E6 carboxy-terminus (HECT) domains define a sub-family of E3 ubiquitin ligases. HECT domains recruit the E2 ubiquitin conjugating enzyme and partici...
The E3 ubiquitin ligases are the largest family among all three enzymes and classified into different families based on their structure, function, and substrate specificity. The major classes of the E3 ubiquitin ligases are; RING (Really Interesting New Gene), HECT (Homologous to E6-associated ...
Deubiquitinating enzymes Drp1: Dynamin-related protein 1 ER: Endoplasmic reticulum Fis1: Fission 1 MDV: Mitochondrial-derived vesicle Mfn1: Mitofusin1 Mfn2: Mitofusin2 MID49 and MID51: Mitochondrial dynamics of 49 and 51 kDa protein mtDNA: Mitochondrial DNA OPA1: Optic atrophy 1 ...
Ubiquitinprotein taggingis catalyzed by an enzymatic cascade involving three families ofenzymes, a ubiquitin activating enzyme (E1),ubiquitin conjugating enzymes(E2), andubiquitin ligases(E3) (Gropper et al., 1991; Jentsch, 1992). The first step begins with the E1 enzyme forming athioesterbond bet...