This article aimed to provide a review on the role of ubiquitination and de-ubiquitination, especially ubiquitin ligase enzymes and de-ubiquitinating enzymes, in the above four pathways. We hope that our work can contribute to the research and development of treatment strategies for innate immunity...
Ubiquitination-mediated protein modifications are increasingly recognized as key regulatory events in many basic cell biology processes. A key class of enzymes called ubiquitin ligases, which has been shown to play a crucial role in the ubiquitination process, can positively or negatively regulate T cel...
ubiquitination can significantly reduce half life of the ubiquitinated protein. This isopeptide bond is generated between an internal lysine of the target protein and the C-terminal glycine of the ubiquitin moiety. Ubiquitination is mediated by a cascade of three individual enzymes. First, ubiquitin ne...
In the last step, a member of a highly diverse class of enzymes known as ubiquitin ligases (E3) recognizes the specific protein to be ubiquitinated and catalyzes the transfer of ubiquitin from E2 to this target protein. 最后,高度保守的泛素连接酶 (E3)家族中的一员(根据底物蛋白质的不同而不...
The ubiquitination process consists in adding ubiquitin chains on target proteins, which leads to mono- or polyubiquitination of the protein that is then degraded by the proteasome.1 The ubiquitination cascade requires the successive action of three enzymes. The first enzyme (E1) involved in the ...
The E3 ubiquitin ligases are the largest family among all three enzymes and classified into different families based on their structure, function, and substrate specificity. The major classes of the E3 ubiquitin ligases are; RING (Really Interesting New Gene), HECT (Homologous to E6-associated ...
Enzymes of the SUMO Modification Pathway Localize to Filaments of the Nuclear Pore Complex SUMOs are small ubiquitin-related polypeptides that are reversibly conjugated to many nuclear proteins. Although the number of identified substrates has gr... H Zhang,H Saitoh,MJ Matunis - 《Molecular & ...
Notably, UBR5 was one of the most upregulated E3 enzymes (Supplementary Table 2). UBR5 shows a striking preference for Lys48 linkages of ubiquitin36, which is the primary signal for proteasomal degradation19. Under proteotoxic stress, UBR5 cooperates with Lys11-specific ligases to produce K11/...
Ubiquitin related enzymes and plant-specific ubiquitin ligase ATL family in tomato plants 来自 NCBI 喜欢 0 阅读量: 44 作者:X Li,Y Hasegawa,Y Lu,T Sato 摘要: Due to their immobility, plants have developed sophisticated mechanisms to robustly monitor and appropriately respond to dynamic changes in...
Really interesting new gene (RING) domains coordinate zinc ions and often mediate binding of E2 ubiquitin conjugating enzymes. HECT domain Homologous to E6 carboxy-terminus (HECT) domains define a sub-family of E3 ubiquitin ligases. HECT domains recruit the E2 ubiquitin conjugating enzyme and partici...