Regulation of ubiquitin protein ligase activity in c-Cbl by phosphorylation-induced conformational change and constitutive activation by tyrosine to glutamate point mutations. J Biol Chem. 2004; 279 :28017–28027.Kassenbrock CK, Anderson SM. Regulation of ubiquitin protein ligase activity in c-Cbl ...
regulation of ubiquitin-protein ligase activity 青云英语翻译 请在下面的文本框内输入文字,然后点击开始翻译按钮进行翻译,如果您看不到结果,请重新翻译! 翻译结果1翻译结果2翻译结果3翻译结果4翻译结果5 翻译结果1复制译文编辑译文朗读译文返回顶部 泛素蛋白连接酶的活性的调控...
[49]. Nedd8 is a ubiquitin-like protein that modifies cullins, the core scaffolds of CRLs. Cycles of cullin neddylation and deneddylation are required for proper ligase activity of the assembled holoenzymes. Thus, perturbation of neddylation dynamics compromises the ubiquitination and turnover of ...
M. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc. Natl Acad. Sci. USA 98, 5134–5139 (2001). Article CAS PubMed PubMed Central Google Scholar Ekholm-Reed, S. et al. Mutation of ...
Trim31-mediated increase in polyubiquitination of Rhbdf2 could be greatly observed in the presence of K48-loading vector, but not with other vectors (Fig.6g). It is generally considered that the RING-finger domain mutant of Trim31 has virtually lost its E3 ubiquitin ligase activity. Given the...
Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1 G Levkowitz,H Waterman,SA Ettenberg,... 被引量: 0发表: 1999年 Insulin-Dependent Diabetes Affects Testicular Function by FSH- and LH-Linked Mechanisms c-kit, insulin-like growth ...
A DNA damage-induced ubiquitylation of proteasome controls its proteolytic activity. Oncotarget. 2013;4:1338–48. Article PubMed PubMed Central Google Scholar Jevtić P, Haakonsen DL, Rapé M. An E3 ligase guide to the galaxy of small-molecule-induced protein degradation. Cell Chem Biol. ...
Here, we show that RPM-1, an atypical RING E3 ubiquitin ligase in the PAM/Highwire/RPM-1 (PHR) protein family29,30,31, functions via ubiquitin ligase activity to degrade ULK and restrict autophagy broadly in the nervous system ofC. elegans. Interestingly, RPM-1 inhibits ULK and autophagosom...
E3 Ubiquitin-Protein Ligase SIAH1 (SIAH1) (C-Term) 抗体 公司简介 上海钰博生物科技有限公司是2012年5月由“海归”组成的创业团队与两个专业投资机构发起成立的,以开发生产科研试剂和特色检验产品为方向,经过两年多的努力,已经建立了免疫学和分子生物学的五个技术平台,开发了ELISA/ELISpot酶联免疫试剂盒、重组蛋...
Itchy, a Nedd4 Ubiquitin Ligase, Downregulates Latent Membrane Protein 2A Activity in B-Cell Signaling. 2003. Itchy, a Nedd4 ubiquitin ligase, downregulates latent membrane protein 2A activity in B-cell signaling. J Virol 77:5529 -5534. https://doi.org... Ikeda,Akiko,Caldwell,... - 《...