Immune EscapeImmune escape is one of the hallmarks of cancer development and metastasis. It is characterized by the lack of ability of the immune system to eliminate transformed cells prior to and after tumor...doi:10.1007/978-3-642-27841-9_2975-2Jiahua Qian...
Targeting these escape mechanisms at earlier stages might prevent the tumor from developing the resistance that currently limits the success of immunotherapies. In this review we explore the implications of GIE alterations in cancer, focusing on their prevalence, timing, and role in immunotherapy ...
Cancer immune escape: implications for immunotherapy, Granada, Spain, October 3-5, 2011. Cancer Immunol Immunother. 2012;61:739-45.Aptsiauri N., Cabrera T., Garcia-Lora A., Garrido F.: Cancer im- mune escape: implications for immunotherapy, Granada, Spain, October 3-5, 2011. Cancer ...
et al. Allele-specific HLA loss and immune escape in lung cancer evolution. Cell 171, 1259–1271.e1211 (2017). Article CAS Google Scholar Thielens, A., Vivier, E. & Romagné, F. NK cell MHC class I specific receptors (KIR): from biology to clinical intervention. Curr. Opin. ...
Studies have characterized the immune escape landscape across primary tumors. However, whether late-stage metastatic tumors present differences in genetic immune escape (GIE) prevalence and dynamics remains unclear. We performed a pan-cancer characteriza
Cancer immune surveillance is considered to be an important host protection process to inhibit carcinogenesis and to maintain cellular homeostasis. In the interaction of host and tumour cells, three essential phases have been proposed: elimination, equilibrium and escape, which are designated the 'three...
Immune escape is a critical gateway to malignancy. The emergence of this fundamental trait of cancer represents the defeat of immune surveillance, a potent, multi-armed and essential mode of cancer suppression that may influence the ultimate clinical impact of an early stage tumor. Indeed, immune ...
To extend such benefits to more cancer patients, it is necessary to understand why some patients experience primary or secondary immune escape, in which the immune response is incapable of eradicating all cancer cells. Understanding immune escape from PD-L1/PD-1–targeted therapy will be important...
many believe, as healthy cells somehow escape the mechanisms that regulate cell growth and turn cancerous. Fortunately,antigens on their surfaces sometimes alter slightly, changing from self to non-self. Thus the cells become targets for Killer T-cells, like these surrounding this large cancer ...
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (for example, those with microsatellite instability). Whether low TMB cancers, which are largely refractory to immunotherapy, harbor potent...