The activation of caspase-1 by inflammasomes cleaves proIL-1β into mature biologically active IL-1β that is released from cells via a non-classical, endoplasmic reticulum-independent secretory pathway directly from the cytoplasm via Gasdermin D membrane pores. IL-1β binds to its heterodimeric ...
(Matt et al., 2016). IL-1 family and inflammasome-associated genes are also subject toepigenetic modificationin cells from patients with cryopyrin-associated periodic syndromes, conditions characterized by IL-1β-mediated systemic inflammation (Vento-Tormo et al., 2017). Together, these data ...
is a monomeric secreted protein that may be released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins.Anti-IL-1 beta antibody is ideal for investigators involved in Cardiovascular and Immunology research....
reflux-mediated induction of IL1β using in vitro models was higher inEACcells than cells of squamous origins, most likely owing to differences in NF-κB status.39,40Evidence from murine modeling suggests that overexpression of IL1β in mouseforestomachmay lead to IL6-dependent intestine-like ...
is a monomeric secreted protein that may be released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. Uniprot ID P01584 推荐稀释比 ELISA:1:500 - 1:2,000Flow Cytometry:User OptimizedIHC:1:100 - 1:200IP:1:400 - 1:800WB:1:1,000相关...
andhematopoietic celltypes. It is produced and released by unconventional mechanisms upon activation by microbial ligands, cytokines, or mechanical stress. In addition, IL-33 is constitutively stored in the nucleus of endothelial cells, epithelial cells, and keratinocytes and may be released afterinjury...
Natural killer (NK) cells, such as CD8+cytotoxic T cells, can be activated without binding to MHC I class complexes. NK-cell function is controlled by cytokines andinterferonsreleased from macrophages and dendritic cells (IL12, IL18, Il2, and others) during viral infection and by the binding...