UVB induced the release of mature IL-18 and IL-1β but NLRP3 contributed only to the secretion of IL-1β. At the mechanistic level, the release of IL-1β was regulated by K + efflux, whereas the secretion of IL-18 was dependent on ROS production. As well as K + efflux, the ...
(IκB), leading to the release and nuclear translocation of NF-κB. NF-κB then enhances transcription of genes for cytokines (IL-1α, IL-1β, IL-6, and TNFα), chemokines (CCL2 and CCL3), celladhesion molecules(ICAM-1 and VCAM-1), andinterferons(IFN-α, IFN-β, and IFN-γ)....
Effect of amphotericin B on the release of inflammatory cytokine IL-1βthrough activation of TLR2/NF-κB signaling pathway in THP-1 cells 在线阅读 下载PDF 引用 收藏 分享 摘要 目的:探讨两性霉素B对人急性单核细胞白血病细胞系(THP-1)Toll样受体2(TLR2)/核转录因子(NF-κB)信号通路及产生白细胞介...
different genetic lesions associated with IBD development in animal models are associated with increased IL-1b.33 Recently, our work and others have demonstrated that inflammasome-regulated IL-1b release is a key event for the progression from colitis to cancer.8,9 We found that complement deficie...
Using electrochemiluminescence, flow cytometry and western blots, CC-90009-induced IL-1b release was observed in AML cell lines and primary AML bone marrow mononuclear cells. Induction of IL-1b was typically observed after caspase 3 and 8 activation, suggesting a cell-death-related mechanism ...
Investigation of the mechanism disclosed that luxeptinib does not inhibit the assembly of the NLRP3 inflammasome but disables its ability to cleave and activate caspase-1 that is required for IL-1β release. It also inhibits the kinases p38MAPK, ERK1/2, SAPK/JNK and activation of ...
Non-canonical secretion of IL-1β from monocytes downstream of activated NLRP3 inflammasomes is the best-characterized model; this is mediated by caspase-1 cleavage of GSDMD and N-GSDMD plasma membrane (PM) pore formation to permit release of IL-1β and induction of pyroptosis. NLRP3 is a ...
Type Mouse Anti Human Monoclonal. Introduction Interleukin-1b is produced by activated macrophages, IL-1B stimulates thymocyte proliferation by inducing il-2 release, b-cell maturation and proliferation, and fibroblast growth factor activity. IL1B proteins are involved in the inflammatory response, bei...
背景资料 IL-1 beta (also known as Interleukin-1 beta,IL-1?and catabolin) is produced by activated macrophages.IL-1 stimulates thymocyte proliferation by inducing IL-2 release,B-cell maturation and proliferation,and fibroblast growth factor activity.IL-1 proteins are involved in the inflammatory ...
Potassium efflux, activation of P2X7 receptor and intracellular reactive oxygen speciesare also important factors required for fullerenols-induced IL-1β release. Stronger NF-κB signal triggered by Gd@C82(OH)22 is in agreement with higher pro-IL-1β expression than C60(OH)22. Interestingly, ...