IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response. It is identified as endogenous pyrogens, and is reported to stimulate the release of prostaglandin and...
Granulocyte colony-stimulating factor at- tenuates LPS-stimulated IL-1b release via suppressed processing of proIL-1b, whereas TNF-a release is inhibited on the level of proTNF- a formation. Eur J Immunol 2002; 32:1717-25.Boneberg, E.M., Hartung, T., 2002. Granulocyte colony-...
B cells (NF-κB).36The binding of IL-1β to IL-1R1 leads to dimerization with the IL-1 receptor accessory protein (AcP). The resulting signaling cascade acts through MyD88 to degrade the inhibitor for NF-κB (IκB), leading to the release and nuclear translocation of NF-κB. NF-κB...
The aim of this study was to determine the extent to which luxeptinib interferes with the release of IL-1β, IL-6 and TNFα from THP-1 monocytes and bone marrow-derived macrophages following endotoxin exposure and priming of the NLRP3 inflammasome. Luxeptinib inhibited the release of all...
The caspase-1 inhibitor zYVAD and RNA silencing of the NALP3 receptor reduced the particle-induced IL-1β release in the RAW264.7 macrophages. Furthermore, inhibitors of phagocytosis, endosomal acidification, and cathepsin B activity reduced the IL-1β responses to the different particles to a ...
Furthermore, although lipopolysaccharide challenge was sufficient to drive IL-1b release in neutrophil, C5a potently amplified this effect (Figure 6c), indicating synergistic actions of commensal flora-derived lipopolysaccharide and C5a on IL-1b production in the context of CAC. Thus, complement ...
嵌合抗原受体T细胞(CAR-T细胞)治疗多发性骨髓瘤(MM)与其他B细胞肿瘤有相似的细胞因子释放综合征(cytokine release syndrome,CRS)发生率,超过80%的患者发生3级及以上血液学毒性和几乎100%的免疫学毒性。MM患者CAR-T细胞治疗后CRS的发生率可高达90%,其中3～5级CRS发生率为5%左右。
B-cell maturation and proliferation, mitogenic FGF-like activity and stimulation of the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant rat IL-1β is a 17.4 kDa protein ...
Both IL-1α and IL-1β bind to the same receptor and have similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity...
(Fig.1a, b). Despite the notable ablation ofIl1r1in mature adipocytes of chow diet-fed IL1R1AKOmice, no major changes were observed in mRNA levels of classical adipocyte or inflammatory markers, body weight development, food-intake, glucose, insulin, or IL-1β levels during fasting-...