肾癌是一种死亡率高且难以检测的癌症,研究人员在单细胞水平上对肾癌进行的最全面研究中,发现了一个潜在的治疗肾癌的药物靶点——IL1B巨噬细胞(macrophages)。来自威康桑格研究所(Wellcome Sanger Institute)、剑桥大学(the University of Cambridge)和剑桥大学医院(Cambridge University Hospitals)的研究人员确认了巨噬细...
This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation...
IL-1β, one of the major pro-inflammatory cytokine produced by macrophages, has been shown to be a key contributor to the pathogenesis ofT2DM. IL-1β signaling occurs through the IL-1 receptor-I and leads to the activation of NF-κB pathways and the generation of otherinflammatory mediators...
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This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation...
Natural killer (NK) cells, such as CD8+cytotoxic T cells, can be activated without binding to MHC I class complexes. NK-cell function is controlled by cytokines andinterferonsreleased from macrophages and dendritic cells (IL12, IL18, Il2, and others) during viral infection and by the binding...
该IL1B Polyclonal Antibody. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important medi...
背景资料IL-1 beta (also known as Interleukin-1 beta,IL-1?and catabolin) is produced by activated macrophages.IL-1 stimulates thymocyte proliferation by inducing IL-2 release,B-cell maturation and proliferation,and fibroblast growth factor activity.IL-1 proteins are involved in the inflammatory res...
背景资料IL-1 beta (also known as Interleukin-1 beta,IL-1?and catabolin) is produced by activated macrophages.IL-1 stimulates thymocyte proliferation by inducing IL-2 release,B-cell maturation and proliferation,and fibroblast growth factor activity.IL-1 proteins are involved in the inflammatory res...
Gene SummaryThe protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the infla...