在 Stat6-/- BMDMs 中表达 WT STAT6 几乎完全取消了条件培养基的衰老诱导活性,而表达功能缺失突变体 STAT6(Y641F)则没有任何影响。当作者通过骨髓移植(BMT)检测Stat6-/-巨噬细胞的体内功能时,在移植6周后获得了约60%的嵌合体,作者观察到Stat6-/-嵌合体小鼠的运动功能降低(通过悬吊、转体和跑步机测试进行检...
SignallingTh2 cellsNa茂ve T helper cells differentiate into Th1 and Th2 subsets, which have unique cytokine signatures, activators and transcriptional targets. The Th1/Th2 cytokine milieu is a key paradigm in lineage commitment, and IL-4 (Il4), IL-13 (Il13) and Stat6 are important ...
JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcrip... of the STAT signaling pathways, but not ERK-dependent pathways, is essential for down-regulation of the major cartilage-specific mat...
天津医科大学 硕士学位论文 IL-4/STAT6信号转导通路中Igε基因转录抑制分子机制的初探 姓名:*** 申请学位级别:硕士 专业:免疫学 指导教师:** 20100501 天津医科大学硕士学位论文 中文摘要 研究目的;STAT6是STATs家族的一员,可被细胞因子IL.4特异性激活。IL-4 与其受体结合后,循JAK/STAT6信号转导通路,将活化...
已经发现IL-4介导成年斑马鱼脑中的实验性阿尔茨海默氏病模型中神经干细胞与经历神经变性的神经元之间的串扰,并通过其细胞内效应子STAT6的磷酸化引发再生级联反应。 IL-4也已经显示,以驱动有丝分裂,分化和转移中横纹肌肉瘤。IL-4和其他Th2细胞因子一起参与过敏性哮喘患者肺部观察到的气道炎。 一、IL-4的功能 白介...
The acquisition of an IL-4-producing phenotype in Th2 cells requires IL-4 signaling through the STAT6 pathway during T cell differentiation. In this study we demonstrate that, unlike in naive T cells, IL-4 is not necessary for the development of an IL-4-producing phenotype in mast cells....
NOD.B10-H2(b).C-Stat6(-/-) mice, like NOD.B10-H2(b).IL4(-/-) mice, are unable to synthesize IgG1 Abs, an observation that correlates with an inability to develop end-stage clinical SjS-like disease. These data imply a requirement for the IL-4/STAT6-pathway for onset of the ...
Batf expression in Tfh cells is regulated by IL-6/Stat3 and the IL-4/Stat6 pathway. Batf controls IRF4 expression and also partners with IRF4 to bind to the CNS2 region of IL-4 locus thus activating IL-4 transcription. c-Maf, a target gene of Batf also controls the expression of...
NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Using a mouse model in which tumors show a growth-regression-recurrence pattern, we investigated the mechanisms for down-regulation of cytotoxic T lymphocy... M Terabe,S Matsui,N Noben-Trauth,....
elsev /locate/moli mm IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis Lei Bao a , Vivian Y. Shi a , Lawrence S. Chan a,b,c,∗ a Department of Dermatology, University of Illinois, Chicago, IL, ...