Jak和Stat是许多调节细胞生长、分化、存活和病原体抵抗信号通路中的关键部分,这一通路涉及到IL-6(gp130)受体家族,它帮助调节B细胞的分化,浆细胞生成和急性期反应。IL-6结合引起受体的二聚化同时激活受体结合的Jak蛋白,活化的Jak蛋白对受体和自身进行磷酸化。这些磷酸化的位点成为带有SH2结构的Stat蛋白和接头蛋白的...
①JAK-STAT通路 是一条由细胞因子刺激的信号转导通路,参与细胞的生长、分化、凋亡以及免疫调节等许多重要的生物学过程。 ○IL-6与其受体复合物(包括IL-6受体和gp130)结合,导致受体的聚集; ○这会激活Janus激酶(JAK),JAK磷酸化gp130和其他细胞内JAK蛋白; ○磷酸化的gp130允许STAT蛋白结合并磷酸化,形成磷酸化的ST...
The activated JAK-STAT pathway has been shown to contribute to angiotensinogen (AGT) stimulation in cultured renal proximal tubular cells (PTC). Therefore, this study was performed to demonstrate that activation of JAK-STAT pathway by IL-6 derived from Ang II-treated MΦ mediates AGT up...
.白介素六IL一通过JKAS/TAT信号通路下调LXRa转录调节的三磷酸腺昔结合盒转运体1A/1GBA以1/1G表达Interleukin一6downregulatesLXR一dePendentexPressionofABCAIandABCGIviaaJAK/STATsignalingPathway一dePendentway肖继莫中成刘协红胡炎伟李晓旭、唐朝克’南华大学心血管病研
JAK/STAT 信号通路在IL. 6介导肾小管上皮细胞转分化中的作用JAK/STAT 信号通路在IL. 6介导肾小管上皮细胞转分化中的作用专业: 内科学博士研究生: 詹林达导师: 余学清教授摘要已有研究表明, 免疫炎症反应导致。 肾小球、 小管、 间质病变时, 肾细胞IL. 6的表达增加; 进展性肾脏疾病肾小管及间质出现大量单...
The Jak/Stat pathway mediates the effects of cytokines, like erythropoietin, thrombopoietin, and G-CSF, which are protein drugs for the treatment of anemia, thrombocytopenia, and neutropenia, respectively. The pathway also mediates signaling by interferons, which are used as antiviral and antiproliferat...
transcription (IL-6/JAK/STAT) pathway has been the focus of research for a number of years and IL-6 has an established role in MM drug resistance... KA Monaghan,T Khong,CJ Burns,... - 《Leukemia》 被引量: 96发表: 2011年 Pyrrolidine Dithiocarbamate Inhibits lnterleukin-6 Signaling thro...
Investigations of the efficacy of IL-6/JAK/STAT3 inhibitors, in combination with immune-checkpoint inhibitors, are warrantedAbstract The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In the...
结果提示,JAK-STAT 信号通路及炎症因子IL-6 、IL-8 参与中波紫外线照射HUVECs 细胞损 伤的调控。 关键词 中波紫外线,人脐静脉血管内皮细胞,JAK-STAT 信号通路,IL-6 ,IL-8 中图分类号 TL7 DOI: 10.11889/j.1000-3436.2016.rrj.34.020204 Effect of UVB irradiation on JAK-STAT pathway and IL-6, L-8...
To confirm the role of IL-6/JAK/STAT3 pathway in mediating sevoflurane-enhanced lung metastases, we then tested the effect of interrupting the IL-6/JAK/STAT3 signaling cascade with a JAK inhibitor AZD1480 in 4T1 model. Prior to the surgery, mice were dosed by oral gavage once with vehicles...