IL6/STAT3信号转导通路PCR芯片IL6/STAT3 Signaling Pathway PCR Array IL6/STAT3信号转导通路PCR芯片可检测参与IL6/STAT3信号的激活和下游效应的84个关键基因的表达,可用于研究IL6/STAT3信号通路的活性状况:激活、抑制或不变。炎症性细胞因子IL6是STAT3的激活分子的一员,通过其受体IL-6(IL6R/IL6ST(GP130))...
In vitro, IL-6 enhanced SLN transcription and induced ROS production, and blocking the IL-6 receptor resulted in decreased ROS generation in skeletal muscle cells.IL-6/JAK/STAT3 signaling pathway was abnormally activated in patients with JDM. IL-6 may be involved in the pathogenesis of muscle ...
The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In the tumour microenvironment, IL-6/JAK/STAT3 signalling acts to drive the proliferation, survival, invasiveness, and metastasis of tumou...
To conclude, our results support the concept that IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma. 展开 关键词: Cholesteatoma IL-6 STAT3 ...
学校代码:1085学号:013430硕士学位论文(学术学位)IL-6/JAK/STAT3信号通路介导EGFR活化调控PD-L1表达并影响细胞增殖作用机制研究IL-6/JAK/STAT3signalingpathwaymediatedtheregulationoftheexpressionofPD-L1bytheactivationofEGFRandtheinfluencemechanismofcellprolife
5. IL6/JAK2/STAT3信号通路介导小胶质细胞M2极化 在添加F3-CM或iL- 6的培养基中加入不同浓度的托珠单抗后,HMO6和CHME5细胞中CD206和Arg1的表达水平下降(Fig 5a).接下来分析JAK/STAT通路成员如JAK1、JAK2、STAT3和STAT1的表达水平。发现可以通过添加IL6或F3-CM刺激HMO6或CHME5细胞,而在托珠单抗治疗的情况下磷...
STAT3 inhibitors for the treatment of SMARCB1-deficient bladder cancer. Low SMARCB1 expression in BLCA tumors is associated with worse patient outcomes and IL6/JAK/STAT3 pathway upregulation Fig. 1: SMARCB1 deficiency is associated with worse outcomes and enrichment for STAT3 signaling....
但是将巨噬细胞肌注至萎缩的肌肉中后,不同于细胞实验,在萎缩的 肌肉中Qesmin、Myod Pax7和Myosin的表达都出现了明显的上升。 结论:在慢性失神经的肌肉萎缩中,IL-6主要通过JAK/STAT3通路来 促进肌肉卫星细胞的增殖和分化。 而巨噬细胞可能通过一种间接的方 式促进萎缩肌肉中卫星细胞的增殖和分化。
摘要 目的:探讨苦豆碱(ALO)调节IL-6/酪氨酸激酶1(JAK1)/信号转导和转录激活因子3(STAT3)通路对结直肠癌(CRC)细胞行为的影响。方法:SW480分为CK组(正常培养的SW480细胞)、ALO低剂量组(AL...展开更多 Objective:To investigate the effects of aloperine(ALO)on cell behavior of colorectal cancer(CRC)cells ...
通路在炎症性肠病中的潜在治疗作用张燕燕(综述) 孙梅(审校) 【摘要】 在免疫和炎症反应中,IL-6 是多效性的细胞因子,它通过激 Janus 激酶(Januskinase,JAK) /信号转录与激活因子 3(signaltransducerandactivatoroftranscription3,STAT3) / 细胞因子信号传导抑制因子 3(suppressorofcytokinesignaling3,SOCS3)起重要...