总之,ARG1可能是STAT3的潜在靶基因,介导il6诱导的M2极化。 Fig 5. IL6/JAK2/STAT3信号通路介导小胶质细胞M2极化 6.靶向IL6/JAK2/STAT3信号通路能抑制A549-F3体内转移 体外数据表明IL6在M2极化中的关键作用,于是作者提出抑制IL6是否...
Amara, C.S., Kami Reddy, K.R., Yuntao, Y.et al.The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer.Nat Commun15, 1373 (2024). https://doi.org/10.1038/s41467-024-45132-2 Download citation ...
IL-6细胞因子家族的成员是治疗感染、炎症、自身免疫和癌症的药物靶点。药物类别包括针对特定细胞因子或细胞因子受体的单克隆抗体和重组蛋白模式(如上图所示),以及调节受体信号传导活性或与膜糖蛋白130 (gp130)或Janus激酶(JAK)相关的细胞内机制的小分子干预措施。图中显示了IL-6细胞因子家族中具有代表性的细胞因子-细...
5. IL6/JAK2/STAT3信号通路介导小胶质细胞M2极化 在添加F3-CM或iL- 6的培养基中加入不同浓度的托珠单抗后,HMO6和CHME5细胞中CD206和Arg1的表达水平下降(Fig 5a).接下来分析JAK/STAT通路成员如JAK1、JAK2、STAT3和STAT1的表达水平。发现可以通过添加IL6或F3-CM刺激HMO6或CHME5细胞,而在托珠单抗治疗的情况下磷...
IL-6(白细胞介素-6)是一种多功能的促炎和抗炎细胞因子,在免疫反应、炎症及代谢调节中发挥关键作用。IL-6通过结合其受体(IL-6R)激活JAK/STAT3信号通路,与多种自身免疫性疾病(如类风湿性关节炎、特应性皮炎)和炎症性疾病(如炎症性...
The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In the tumour microenvironment, IL-6/JAK/STAT3 signalling acts to drive the proliferation, survival, invasiveness, and metastasis of tumou...
学校代码:1085学号:013430硕士学位论文(学术学位)IL-6/JAK/STAT3信号通路介导EGFR活化调控PD-L1表达并影响细胞增殖作用机制研究IL-6/JAK/STAT3signalingpathwaymediatedtheregulationoftheexpressionofPD-L1bytheactivationofEGFRandtheinfluencemechanismofcellprolife
DepartmentHuangDepartmentMonteDepartmentSDepartmentWillisDepartmentGerhardDepartmentMeissnerDepartmentInformaworldJak StatHuang TQ, Willis MS, Meissner G. IL-6/STAT3 signaling in mice with dysfunctional type-2 ryanodine receptor. JAKSTAT. 2015;4:e1158379....
IL-6结合其受体，下游通过JAK-STAT、MAPK-ERK和PI3K-Akt通路传递信号，激活转录。其中STAT3信号通路被认为是癌症炎症的主要途径，在恶性细胞中经常被激活，并在调节肿瘤微环境炎症相关关键基因转录中发挥关键作用。癌症炎症对于抗肿瘤起着双重作用，即具有一定抗肿瘤的作用，但是也促进细胞外基质降解，癌症血管新生，内皮...
To conclude, our results support the concept that IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma. 展开 关键词: Cholesteatoma IL-6 STAT3 ...