Instead, inhibition of STAT3 activity using the JAK inhibitor ruxolitinib decreases breast cancer invasion in vivo. Therefore, IL6/STAT3 and ER oncogenic pathways are functionally decoupled, highlighting the potential of IL6/STAT3-targeted therapies in ER breast cancer....
JAKNK cell cytotoxicityNKG2Dprogrammed death receptor ligand 1Stat3To investigate whether IL-6 signaling affects the susceptibility of castration resistant prostate cancer (CRPC) cells to cytotoxic action of natural killer (NK) cells, CRPC cell lines (having different IL-6 level) were developed by ...
Hallmark signaling pathways associated with inflammatory responses and IL6/JAK/STAT3 signaling pathways were among the top enriched gene sets associated with low SMARCB1 expression (Fig. 1B, C; Supplementary Data 2). Fig. 1: SMARCB1 deficiency is associated with worse outcomes and enrichment for ...
总之,ARG1可能是STAT3的潜在靶基因,介导il6诱导的M2极化。 Fig 5. IL6/JAK2/STAT3信号通路介导小胶质细胞M2极化 6.靶向IL6/JAK2/STAT3信号通路能抑制A549-F3体内转移 体外数据表明IL6在M2极化中的关键作用,于是作者提出抑制IL6是否...
IL-6(白细胞介素-6)是一种多功能的促炎和抗炎细胞因子,在免疫反应、炎症及代谢调节中发挥关键作用。IL-6通过结合其受体(IL-6R)激活JAK/STAT3信号通路,与多种自身免疫性疾病(如类风湿性关节炎、特应性皮炎)和炎症性疾病(如炎症性...
提出可以通过IL6/JAK2/STAT3信号通路调控小胶质细胞表型,探索了新的潜在的预防和治疗方法。 参考文献: Jin, Y., et al., Targeting polarized phenotype of microglia via IL6/JAK2/STAT3 signaling to reduce NSCLC brain metastasis. Signal Transduct Target Ther, 2022. 7(1): p. 52....
Targeting the IL‑6/JAK/STAT3 signalling axis in cancer Daniel E. Johnson, Rachel A. O’Keefe and Jennifer R. Grandis* Abstract | The IL‑6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosi...
The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In the tumour microenvironment, IL-6/JAK/STAT3 signalling acts to drive the proliferation, survival, invasiveness, and metastasis of tumou...
学校代码:1085学号:013430硕士学位论文(学术学位)IL-6/JAK/STAT3信号通路介导EGFR活化调控PD-L1表达并影响细胞增殖作用机制研究IL-6/JAK/STAT3signalingpathwaymediatedtheregulationoftheexpressionofPD-L1bytheactivationofEGFRandtheinfluencemechanismofcellprolife
JAK信号传导被确定为IL-6诱导的软骨分解代谢和伤害感受神经元疼痛信号传导的关键介质。STAT3信号也是软骨分解代谢的有效驱动因素;然而,其抑制对软骨合成代谢有负面影响,并进一步加剧了DRG神经元中疼痛相关的信号传导,表明STAT3抑制剂可能不是合适的DMOAD。ERK信号传导对于IL-6诱导的神经突起和DRG神经元的疼痛信号传导至关...