IL6/STAT3 Signaling Pathway PCR Array IL6/STAT3信号转导通路PCR芯片可检测参与IL6/STAT3信号的激活和下游效应的84个关键基因的表达,可用于研究IL6/STAT3信号通路的活性状况:激活、抑制或不变。炎症性细胞因子IL6是STAT3的激活分子的一员,通过其受体IL-6(IL6R/IL6ST(GP130))传递信号,激活Janus激酶,这又...
蒋建东院士/彭宗根团队:双环醇通过抑制IL-6/STAT3信号通路改善晚期肝病 编者按:慢性进展性肝病包含了从早期肝炎到更为严重的肝纤维化、肝硬化及肝癌阶段,其发生及进展与病毒感染、化学及代谢因素等直接相关。近日,中国医学科学院医药生物技术研究所蒋建东院士/彭宗根团队经过数年研究,揭示双环醇可通过抑制IL-6/STAT3信号...
Conclusions: During differentiation of human MSCs into chondrocytes, the activation of IL-6/STAT3 signaling positively regulated chondrogenic differentiation. The presence of IL-6 around MSC-like cells in the cartilage tissue was evident, suggesting that IL-6 contributes to homeostasis and cartilage ...
这项机制研究揭示肝脏损伤下,驻留Kupffer细胞分泌的炎症信号IL-6诱导了肝细胞的去分化并表达前体基因。信号转导机制上,IL-6是损伤特异的信号,该信号通过肝细胞表达的受体IL6R/gp130能直接激活肝细胞STAT3信号通路诱导肝细胞去分化。转录...
The IL-6/JAK/STAT3 pathway is aberrantly hyperactivated in many types of cancer, and such hyperactivation is generally associated with a poor clinical prognosis. In the tumour microenvironment, IL-6/JAK/STAT3 signalling acts to drive the proliferation, survival, invasiveness, and metastasis of tumou...
IL 6主要通过介导信号转换和转录激活因子3(STAT3)信号传导通路(IL 6/STAT3信号传导通路)来调节肿瘤细胞的增殖和分化。因此,IL 6/STAT3信号传导通路的阻断,对肿瘤具有潜在治疗意义。 【关键词】 肿瘤;白细胞介素6;STAT3转录因子;信号传导TargetingtheIL 6/STAT3signalingpathwayincancertreatment GUOYu qi ,ZhenfengDUAN,...
il6协同gcsf通过激活stat3信号途径增强中性粒细胞促进肿瘤血管生成的功能-il6 cooperates with gcsf to enhance the function of neutrophils in promoting tumor angiogenesis by activating stat 3 signaling pathway.docx 关闭预览 想预览更多内容,点击免费在线预览全文 免费在线预览全文 ...
The expression and activation of SOCS3 expression decreased. STAT3 had a certain effect on the expression of SOCS3, playing a certain regulatory role in ulcerative colitis carcinogenesis. 展开 关键词: Ulcerative colitis, signaling pathways, IL-6, STAT3, SOCS3 被引量: 26 年份: 2015 ...
上述结果表明,PKCβⅡ介导HCC细胞侵袭能力的增强是通过IL-6自分泌方式实现的。 2.4 IL-6/STAT3信号通路参与PKCβⅡ的促HCC细胞侵袭 通过RTFQ-PCR检测PKCβⅡ高表达HCC细胞Huh7和对照组细胞中IL-6受体的表达,结果表明,PKCβⅡ可以...
结果 冬凌草甲素抑 制乳腺癌细胞增殖,诱导乳腺癌细胞自噬和凋亡作用,呈剂量相关性;冬凌草甲素对 IL-6/STAT3 信号通路和 STAT3 磷酸化 均有明显的抑制作用;冬凌草甲素能够上调乳腺癌细胞 p53,剪切型多聚腺苷二磷酸核糖聚合酶(cleaved poly ADP-ribose polymerase,cleaved PARP),剪切型半胱氨酸天冬氨酸蛋白酶-...