Amara, C.S., Kami Reddy, K.R., Yuntao, Y.et al.The IL6/JAK/STAT3 signaling axis is a therapeutic vulnerability in SMARCB1-deficient bladder cancer.Nat Commun15, 1373 (2024). https://doi.org/10.1038/s41467-024-45132-2 Download citation ...
SMARCB1-deficient tumors show an increased IL6/JAK/STAT3 signaling axis in in vivo models and patients. Furthermore, a pSTAT3 selective inhibitor, TTI-101, reduces tumor growth in SMARCB1 KO orthotopic cell line-derived xenografts and a SMARCB1-deficient patient derived xenograft ...
To conclude, our results support the concept that IL-6/JAK/STAT3 signaling pathway is active and may play an important role in the mechanisms of epithelial hyper-proliferation responsible for cholesteatoma. 展开 关键词: Cholesteatoma IL-6 STAT3 ...
Objectives: We investigated the changes in the IL-6 and STAT3 expression levels in cachectic and non-cachectic patients with gastric, lung and breast cancer and evaluated the association between IL-6 and STAT3 levels and cancer types in terms of cachexia condition. Background: Cancer-associated ca...
IL6/JAK1/STAT3 Signaling blockade in endometrial cancer affects the ALDHhi/ CD126+ stem-like component and reduces tumor burden. Cancer Res. 2015; 75:3608-3622.van der Zee, M., Sacchetti, A., Cansoy, M., Joosten, R., Teeuwssen, M., Heijmans-Antonissen, C., et al. (2015). ...
The NFAT1-mediated IL6/JAK-STAT signaling pathway has been observed to contribute to malignant progression in glioma patients. To predict the overall survival (OS) rate of these patients, a prognostic model was developed based on this pathway. Two datasets, mRNAseq_325 and mRNAseq_693, were ...
In the tumor tissues, the expression of hypoxia inducible factor (HIF)-1伪 (PLonger HPC followed by reperfusion accelerated hepatocellular carcinoma growth through the induction of HIF-1伪 and the activation of the IL-6-JAK-STAT3 signaling pathway....
Longer warm ischemia can accelerate tumor growth through the induction of HIF-1αand the IL-6-JAK-STAT3 signaling pathway in a rat hepatocellular carcinoma model. Hamaguchi Y,Mori A,Fujimoto Y,et al. J Hepatobiliary Pancreat Sci . 2016
Longer warm ischemia can accelerate tumor growth through the induction of HIF-1αand the IL-6-JAK-STAT3 signaling pathway in a rat hepatocellular carcinoma model. Hamaguchi Y,Mori A,Fujimoto Y,et al. J Hepatobiliary Pancreat Sci . 2016
IL-6/JAK1/STAT3 signalingCyclin D1BPH Benign prostatic hyperplasiaIL-6 Interleukin-6IL-1β Interleukin-1βTNF-α Tumor necrosis factor-alphaNF-κB Nuclear factor-kappa BBenign prostatic hyperplasia (BPH) is a widespread disorder in elderly men. Cinnamaldehyde, which is a major constituent in ...