在 Stat6-/- BMDMs 中表达 WT STAT6 几乎完全取消了条件培养基的衰老诱导活性,而表达功能缺失突变体 STAT6(Y641F)则没有任何影响。当作者通过骨髓移植(BMT)检测Stat6-/-巨噬细胞的体内功能时,在移植6周后获得了约60%的嵌合体,作者观察到Stat6-/-嵌合体小鼠的运动功能降低(通过悬吊、转体和跑步机测试进行检...
Similar to mouse BMDM, the IL-4-induced hRetn in human PBMCs was blocked by STAT6 inhibitors. Collectively, these data suggest that IL-4 signaling via STAT6 induces hRetn and these results are supportive of a novel signaling pathway for hRetn. Future studies will investigate the functional ...
研究目的;STAT6是STATs家族的一员,可被细胞因子IL.4特异性激活。IL-4 与其受体结合后,循JAK/STAT6信号转导通路,将活化信号通过蛋白质的相互 作用逐级传递,最终激活特异性转录激活因子STAT6并启动靶基因的转录与表 达,促进靶蛋白的合成。I【广4/STAT6信号通路的过度活跃参与包括哮喘等变态 ...
已经发现IL-4介导成年斑马鱼脑中的实验性阿尔茨海默氏病模型中神经干细胞与经历神经变性的神经元之间的串扰,并通过其细胞内效应子STAT6的磷酸化引发再生级联反应。 IL-4也已经显示,以驱动有丝分裂,分化和转移中横纹肌肉瘤。IL-4和其他Th2细胞因子一起参与过敏性哮喘患者肺部观察到的气道炎。 一、IL-4的功能 白介...
IL-4, through its activation of STAT6, upregulates GATA3 expression and also suppresses TH1 and TH17 cell responses, partly through the upregulation of growth factor independent 1(GFI1), a transcriptional repressor of IFN&gammal and IL-17 production. IL-4 induces macrophage activation and TSLP...
关键词:COPD;喘可治注射液;Thl/Th2失衡;信号通道;实验研究 V TheeffectofChuankezhiinjectiononIL一12/STAT4andIL-4/STAT6pathwayinchroniCobstructivepuImonarydiseaseratsSpecialty:internalmediCineoftraditionalOhinesemediCiBeAuthor:HUANGChun—meTutor:ProfessorofLIUXiao—hongAbstractObjectiVeTostudytheeffectsofChuanke...
Along with immunoprecipitation and immunoblot analyses, these data implicate the JAK/STAT6 pathway in AI regulation. Dexamethasone (Dex) and interferon (IFN)-gamma were investigated for their effects on AI induction. Dex (1 microM) and IFN-gamma (100 U/ml) alone had no effect on basal AI ...
elsev /locate/moli mm IL-4 regulates chemokine CCL26 in keratinocytes through the Jak1, 2/Stat6 signal transduction pathway: Implication for atopic dermatitis Lei Bao a , Vivian Y. Shi a , Lawrence S. Chan a,b,c,∗ a Department of Dermatology, University of Illinois, Chicago, IL, ...
2024年6月,印第安纳大学Mark H. Kaplan教授团队在《Proceedings of the National Academy of Sciences》上发表了论文“An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS i...
The acquisition of an IL-4-producing phenotype in Th2 cells requires IL-4 signaling through the STAT6 pathway during T cell differentiation. In this study we demonstrate that, unlike in naive T cells, IL-4 is not necessary for the development of an IL-4-producing phenotype in mast cells....