2.2 肝纤维化 肝纤维化(liver fibrosis)是一种进展性的病理状态,若未能得到有效控制,可能进一步发展为肝硬化,最终需要肝脏移植作为唯一的治疗选择。在肝纤维化过程中,肝星状细胞是主要的成纤维细胞类型,发挥着关键作用。 近年来的研究表明,肝星状细胞高表达IL-11RA(IL-11受体)和糖蛋白130(gp130),并对IL-11有...
2.2 肝纤维化 肝纤维化(liver fibrosis)是一种进展性的病理状态,若未能得到有效控制,可能进一步发展为肝硬化,最终需要肝脏移植作为唯一的治疗选择。在肝纤维化过程中,肝星状细胞是主要的成纤维细胞类型,发挥着关键作用。 近年来的研究表明,肝星状细胞高表达IL-11RA(IL-11受体)和糖蛋白130(gp130),并对IL-11有...
[3] Widjaja AA, Singh BK, Adami E et al. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. Gastroenterology. 2019 Sep;...
2.2 肝纤维化 肝纤维化(liver fibrosis)是一种进展性的病理状态,若未能得到有效控制,可能进一步发展为肝硬化,最终需要肝脏移植作为唯一的治疗选择。在肝纤维化过程中,肝星状细胞是主要的成纤维细胞类型,发挥着关键作用。 近年来的研究表明,肝星状细胞高表达IL-11RA(IL-11 受体)和糖蛋白130(gp130),并对IL-11有...
研究探讨了IL-11信号通路在肝脏星状细胞(HSCs)、肝细胞和多种NASH小鼠模型中的作用。 关键词:IL11,Interleukin 11,adipogenesis inhibitory factor,X209,X203 More information: Widjaja, Anissa A et al. “Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and ...
More information: Widjaja, Anissa A et al. “Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.” Gastroenterology vol. 157,3 (2019): 777-792.e14. doi:10.1053/j.gastro.2019.05.002 ...
IL-11 inhibition offers a promising strategy, with preclinical trials demonstrating its ability to regenerate renal cells, reduce hepatocyte death, and mitigate liver fibrosis. Further research is necessary to fully elucidate the mechanisms of IL-11 inhibition and its therapeutic potential. If successful...
We determined IL-11 expression in the liver, visceral gonadal white adipose tissue (vWAT) and skeletal muscle (gastrocnemius) in mice over a time course of ageing, which revealed progressive up-regulation of IL-11 in all tissues (Fig.1b,cand Extended Data Fig.1a,b). With age, there was...
It is known that X203 treatment has a positive effect on arterial remodeling in the context of hypertension16, on cardiac fibrosis and healing after myocardial infarction15, on liver fibrosis19 and in idiopathic pulmonary fibrosis18. In this study, we showed that inhibiting IL-11 reduced ...
(Interleukin-11,简称IL-11)是一种重要的细胞因子,属于趋化因子家族的一员。在复杂的细胞因子网络中,IL-11发挥着多重作用,涉及造血、免疫调节、炎症反应和组织修复等多个方面。 一、IL-11的基本特性 IL-11是一种由多种细胞产生的细胞因子,包括骨髓基质细胞、成骨细胞、滑膜细胞、成纤维细胞、软骨细胞和滋养细胞...