IL11 was reported to induce the formation of myofibroblasts and their secretion of collagen, while its subcutaneous administration drives the development of pulmonary fibrosis in mice. Less is known as to how IL11 affects epithelial-mesenchymal communication associated with epithelial repair, and ...
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种进展性、严重的肺部疾病。尽管目前已有如nintedanib等治疗药物,但患者的长期临床预后仍不理想,亟需更有效的治疗手段。近年来,研究表明IL-11在肺部疾病中发挥了重要作用,尤其是在由系统性硬化症(systemic sclerosis,SSc)引起的肺纤维化患者中。 Lindahl 等人的研...
14. Ng, B., et al., Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis. Sci Transl Med, 2019. 11(511). 15. Ng, B., et al., Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis. Sci Rep, 2...
白细胞介素-11(Interleukin-11,简称IL-11)是一种重要的细胞因子,属于趋化因子家族的一员。在复杂的细胞因子网络中,IL-11发挥着多重作用,涉及造血、免疫调节、炎症反应和组织修复等多个方面。 一、IL-11的基本特性 IL-11是一种由多种细胞产生的细胞因子,包括骨髓基质细胞、成骨细胞、滑膜细胞、成纤维细胞、软骨...
Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we analyzed the contribution of IL-11 to PH in p
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated. Here we dissect IL11 signaling in fibrobla...
IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system. PMID: 37339207 IL-11 signaling as a therapeutic target for cancer. PMID: 25917632 IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis. PMID...
To study whether TGF-尾1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) indeficient () mice and determines the major downstream mediator of Bmi-1 and crosstalk between p16and reactive oxygen species that regulates SAPF, phenotypes were compared among 7-...
IL-11 induces NLRP3 inflammasome activation in monocytes and inflammatory cell migration to the central nervous system. PMID: 37339207 IL-11 signaling as a therapeutic target for cancer. PMID: 25917632 IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis. PMID...
Fibrosis is a canonical feature of ageing and a hallmark of senescence, and IL-11 is known to be pro-fibrotic in human cells and in young adult mice22,39. We quantified fibrosis in aged vWAT, skeletal muscle and livers of old mice across experimental groups, which showed reversal of tissue...