IL-22 not only plays the role of anti-inflammation and promotion of liver regeneration and tissue repair, but also has a pro-inflammatory effect in liver diseases, and it exerts a protective effect on the liver by reducing fibrosis in some pathological conditions, but there are st...
Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment. Hepatology. 2014;59:1331–42. CAS PubMed PubMed Central Google Scholar Malik S, Want MY, Awasthi A. The emerging roles of gamma-delta...
Interleukin-22 ameliorated renal injury and fibrosis in diabetic nephropathy through inhibition of NLRP3 inflammasome activation Shaofei Wang, et al. (Cell Death&Disease, 2017) EXTRACT FROM INDIGO NATURALIS AND A PROCESS FOR PREPARING THE SAME Lin Yin-ku, et al. (Galderma S.A. patent:US201702662...
作者: None 摘要: Studies in mice suggest that increasing IL-22 expression could help protect against inflammation-induced pulmonary fibrosis. Further details on the research, next steps and licensing status are discussed in the article. DOI: 10.1038/scibx.2014.1014 年份: 2014 收藏...
Therapeutic strengthening of the IL-22–IL-22R system — for example, through the application of recombinant IL-22 or IL-22-inducing small molecules — might have a beneficial impact in liver and pancreas damage, ulcerative colitis, graft-versus-host disease and transplantation of IL-22R1-expres...
(2009) Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride. Hepatology 49: 1683–1694. [25] Tupin E, Kinjo Y, Kronenberg M (2007) The unique role of natural killer T cells in the response to microorganisms. Nat Rev Microbiol 5: ...
The lack of endogenous IL22-receptor signaling (IL22RA knockout) led to exacerbated liver damage, inflammation, apoptosis, and liver fibrosis in female, but not male, mice with NAFLD. Conclusions Our data suggest a sex-dependent hepatoprotective antiapoptotic effect of IL22-receptor signaling during...
(Supplementary Fig.4). To follow the kinetics of this host response, we measured Lcn2 and S100a9 levels after 4 or 16 h of stress, and after 6 or 12 h following release from overnight stress. Enhanced expression ofLcn2andS100a9was seen in both the ileum and liver after 4 h ...
The collagen volume fraction (CVF), the percentage of splenic Th22 cells, plasma IL-22 levels, cardiac IL-22R expression and indicators of myocardial fibrosis were then monitored. Results Compared to control mice at the same time points, AVMC, chronic myocarditis and DCM mice have higher ...
Therapeutic strengthening of the IL-22–IL-22R system — for example, through the application of recombinant IL-22 or IL-22-inducing small molecules — might have a beneficial impact in liver and pancreas damage, ulcerative colitis, graft-versus-host disease and transplantation of IL-22R1-expres...