[1].Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature. 2024. doi:10.1038/s41586-024-07701-9[2].Schafer S, Viswanathan S, Widjaja AA, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. ...
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种进展性、严重的肺部疾病。尽管目前已有如nintedanib等治疗药物,但患者的长期临床预后仍不理想,亟需更有效的治疗手段。近年来,研究表明IL-11在肺部疾病中发挥了重要作用,尤其是在由系统性硬化症(systemic sclerosis,SSc)引起的肺纤维化患者中。 Lindahl 等人的研...
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种进展性、严重的肺部疾病。尽管目前已有如nintedanib等治疗药物,但患者的长期临床预后仍不理想,亟需更有效的治疗手段。近年来,研究表明IL-11在肺部疾病中发挥了重要作用,尤其是在由系统性硬化症(systemic sclerosis,SSc)引起的肺纤维化患者中。 Lindahl 等人的研...
然而,在矽肺纤维化过程中IL-11如何发挥作用尚不清楚。 华中科技大学公共卫生学院马继轩、陈卫红教授团队于2024年7月在Science of The Total Environment上发表了题为“Interleukin-11 drives fibroblast metabolic reprogramming in crystalline si...
3. Beniamin Ng, et al. (2019) Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis.Science Translational Medicine. Vol. 11,Issue 511, eaaw1237发布于 2023-02-13 14:33・北京 细胞株 赞同4添加评论 分享喜欢收藏申请转载 写...
而此前关于IL11因子促进纤维化方面的资料非常匮乏，尤其是关于哺乳动物体内纤维化与IL11之间关系所做出来证明更是零星无几。当这篇名为《Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis》被公之于众之后，在整个医学界引起了轩然大波。IL11与衰老 除了对于心血管系统纤维化问题得到有效防治...
[2].Schafer S, Viswanathan S, Widjaja AA, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552(7683):110-115. doi:10.1038/nature24676 [3].https://www.duke-nus.edu.sg/allnews/duke-nus-breakthrough-advances-quest-to-slow-ageing...
[1].Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature. 2024. doi:10.1038/s41586-024-07701-9 [2].Schafer S, Viswanathan S, Widjaja...
[2].Schafer S, Viswanathan S, Widjaja AA, et al. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017;552(7683):110-115. doi:10.1038/nature24676 [3].https://www.duke-nus.edu.sg/allnews/duke-nus-breakthrough-advances-quest-to-slow-ageing ...
More information: Widjaja, Anissa A et al. “Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.” Gastroenterology vol. 157,3 (2019): 777-792.e14. doi:10.1053/j.gastro.2019.05.002 ...