特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种进展性、严重的肺部疾病。尽管目前已有如nintedanib等治疗药物,但患者的长期临床预后仍不理想,亟需更有效的治疗手段。近年来,研究表明IL-11在肺部疾病中发挥了重要作用,尤其是在由系统性硬化症(systemic sclerosis,SSc)引起的肺纤维化患者中。 Lindahl 等人的研...
特发性肺纤维化(idiopathic pulmonary fibrosis,IPF)是一种进展性、严重的肺部疾病。尽管目前已有如nintedanib等治疗药物,但患者的长期临床预后仍不理想,亟需更有效的治疗手段。近年来,研究表明IL-11在肺部疾病中发挥了重要作用,尤其是在由系统性硬化症(systemic sclerosis,SSc)引起的肺纤维化患者中。 Lindahl 等人的研...
一方面,在炎症的早期阶段,IL-11通过抑制肠上皮细胞的凋亡,维持肠屏障的完整性,起到保护作用;另一方面,在慢性阶段,IL-11的过度表达增强了TGF-β信号通路,促进肠道纤维化和慢性炎症的进展。 因此,在UC慢性阶段,针对IL-11的阻断或抑制疗法(如抗IL-11抗体或IL-11信号通路抑制剂)可能有助于减轻纤维化进展和组织损伤...
导语:IL-11或可被优先考虑作为肺纤维化和IPF的药物靶点。 来源:Medsci 背景特发性肺纤维化(IPF)是一种进行性纤维化肺疾病,侵袭性肺肌成纤维细胞分泌胶原蛋白,破坏肺的完整性。在特发性肺纤维化(IPF)中,侵袭性肌成纤维细胞的慢性活化是肺纤维化瘢...
此后的另一项研究发现,在特发性肺纤维化(IPF)中。IL-11由IPF纤维母细胞分泌并在患者的肺部表达上调,与患者肺部纤维化的严重程度有关。且实验中研究人员合成的IL-11中和抗体可以逆转呈现为细胞的活化,减轻实验中小鼠模型的肺部炎症。 靶向IL-11药物开发
近年来,越来越多的研究发现,IL-11与人类纤维化病症疾病和肿瘤微环境有关,包括非酒精性脂肪性肝炎(NASH),间质性肺疾病(ILD),特发性肺纤维化(IPF),因此IL-11RA抗体药物研发成为新的热点。已有多家药企进入临床试验阶段,其中Lassen Therapeutics公司的抗IL-11R单克隆抗体(LASN01)(目前处于临床1期)和Enleofen公司...
Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell activation has been identified ...
Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we analyzed the contribution of IL-11 to PH in p
In fibroblasts, TGFβ1 stimulates IL11 upregulation that leads to an autocrine loop of IL11-dependent pro-fibrotic protein translation. The signaling pathways downstream of IL11, which acts via IL6ST, are contentious with both STAT3 and ERK implicated. Here we dissect IL11 signaling in fibrobla...
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