5. Klein, W., et al., A polymorphism in the IL11 gene is associated with ulcerative colitis. Genes Immun, 2002. 3(8): p. 494-6. 6. Lim, W.W., et al., Transgenic interleukin 11 expression causes cross-tissue fibro-inflammation and an inflammatory bowel phenotype in mice. PLoS One...
[3] Widjaja AA, Singh BK, Adami E et al. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. Gastroenterology. 2019 Sep;...
研究探讨了IL-11信号通路在肝脏星状细胞(HSCs)、肝细胞和多种NASH小鼠模型中的作用。 关键词:IL11,Interleukin 11,adipogenesis inhibitory factor,X209,X203 More information: Widjaja, Anissa A et al. “Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and ...
慢性无菌性炎症（chronic sterile inflammation）与衰老息息相关，是衰老的重要标志，参与衰老过程并与衰老...
Chronic inflammation is considered a hallmark of aging. In a recent issue of Nature, Widjaja et al. examined genetic and pharmacologic inhibition of interleukin (IL)-11 on aging pathology and found that inhibiting IL-11 signaling increases lifespan and healthspan in mice.Saad Khan...
近日，东南大学附属中大医院肾内科张晓良教授课题组在《Cell Communication and Signaling》期刊在线发表题为：Macrophages release IL11-containing filopodial tip vesicles and contribute to renal interstitial inflammation 的研究论文，该研究首次报道巨噬细胞丝状伪足顶端产生一种独特的「伪足顶端囊泡体」结构，伪足顶端囊...
progenitors. Collectively, these data reveal that IL-11 regulates inflammatory demyelination via a unique combination of immunoregulation and neuroprotection. IL-11 signaling may represent a therapeutic avenue to restrict CNS inflammation and potentiate oligodendrocyte survival in autoimmune demyelinating disease...
[4]Nowarski Roni,Jackson Ruaidhrí,FlavellRichard A. The Stromal Intervention: Regulation of Immunity and Inflammation atthe Epithelial-Mesenchymal Barrier.[J]. Cell,2017,168(3). End 在新的一年里更加努力,更求进步 云南洛宇生物科技有限公司(简称洛宇生物)是云南省第一家有自主研发创新科研平台的第三方...
For healthspan and lifespan, ERK, AMPK and mTORC1 represent critical pathways and inflammation is a centrally important hallmark1–7. Here we examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated
cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27, and IL-31. It is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts. It is found in the plasma mainly during inflammation, and is con...