近日,来自美国耶鲁大学的Richard A. Flavell课题组在Nature上发表了研究论文IL-10 constrains sphingolipid metabolism to limit inflammation,该研究通过系统的研究IL-10信号缺失介导的巨噬细胞脂质组变化,发现鞘脂合成途径代谢通量的增加导致内源性神经酰胺的积累,破坏...
10 is a strong inhibitor of inflammation, it has become a viable biomarker for various diseases and conditions as well as a therapeutic molecule for certain conditions. In addition to elevated levels in parasitic infection, high expression levels of IL-10 are also found in retroviral infections ...
IL-10immune inflammatory diseaselymphocytesregulatory cellIL-10 is an anti-inflammatory cytokine that plays a significant role in controlling inflammation and modulating adaptive immune responses that cause tissue damage. IL-10-producing lymphocytes contribute to the delicate balance between inflammation and ...
the inhibition. However, CD4+CD25+ T reg cells derived from IL-10–deficient mice were still able to suppress allergic inflammation, implying that the IL-10 need not be produced by the T reg cells themselves. Indeed, the authors found that IL-10 was produced by host T cells in the lung...
IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules...
IL-10 Ameliorates Excessive Inflammation in Chronic Pseudomonas aeruginosa Infection in Mice. 1940Interleukin-10Pseudomonas InfectionsRespiratory Tract Infections白细胞介素10假单胞菌感染呼吸道感染1998 Abstracts The American Pediatric Society and The Society for Pediatric Research...
IL-10 producing B cells rescue mouse fetuses from inflammation-driven fetal death and are able to modulate T cell immune responsesPathogenesisExperimental models of diseaseTranslational immunologyUnderstanding the mechanisms leading to fetal death following maternal subclinical infections is crucial to develop...
VLC ceramide production and the associated inflammation. Mechanistically, we find that persistent inflammation mediated by VLC ceramides is largely dependent on sustained activity of REL, an immuno-modulatory transcription factor. Together, these data indicate that an IL-10-driven fatty acid desaturation ...
Interleukin 10, Immunotherapy, VaccineInterleukin 10 is a cytokine with the ability to reduce or terminate inflammation. Chronic viral infection, such as infection of chronic hepatitis B, hepatitis C and HIV, has increased levels of interleukin 10 in peripheral blood. Serum IL-10 levels are ...
In conclusion, we identified the AhR-Src-STAT3-IL-10 signaling pathway as a critical pathway in the immune regulation of inflammatory macrophages, It suggests that AhR may be a potential therapeutic target in immune response. 展开 关键词: aryl hydrocarbon receptor, IL-10, macrophages, inflammation...