Interleukin 10 (IL-10) is an anti-inflammatory cytokine that plays a critical role in the control of immune responses. However, its mechanisms of action remain poorly understood. Here, we show that IL-10 opposes the switch to the metabolic program induced by inflammatory stimuli in macrophages....
Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell activation and cytokine production in innate immune cell types. Loss of IL-10 signalling results in life-threatening inflammatory bowel disease in humans and mice—however, the exact mechanism by which IL-10 s...
Science上就曾发表了一篇题为《Anti-inflammatory effect ofIL-10 mediated by metabolic reprogrammingof macrophages》的文章:来自美国耶鲁大学医学院和哈佛医学院的研究人员以缺乏IL-10信号的小鼠和病人为实验对象,探究了炎症性肠病中炎症因子IL10在巨噬细胞代谢中的作用。 这项研究聚焦于代谢解释了炎症性肠病的发病机...
Interleukin (IL)-10 is an anti-inflammatory cytokine produced by Th2 T helper cells and it has pleiotropic effects in immunoregulation and inflammation. It inhibits the regulation of Th1 T helper cells and MHC class II expression on APC while enhancing B cell survival, proliferation, and ...
具体而言,他们发现IL-10抑制脂多糖诱导的葡萄糖摄取和糖酵解,促进氧化磷酸化。再者,他们还证实IL-10通过诱导一种被称作DDIT4的mTOR抑制剂产生来抑制mTOR活性。相关研究结果发表在2017年5月5日的Science期刊上,论文标题为“Anti-inflammatory effect of IL-...
在近期的Science杂志中一片题为《Anti-inflammatory effect ofIL-10 mediated by metabolic reprogrammingof macrophages》文章中则阐述了IL-10能够抑制巨噬细胞在受到促炎性刺激后诱导发生的代谢程序的改变。因巨噬细胞被细菌病原体激活后发生的葡萄糖摄取和糖酵解增加以及并促...
Interleukin-10 (IL-10) is a key anti-inflammatory cytokine that can limit immune cell activation and cytokine production in innate immune cell types1. Loss of IL-10 signalling results in life-threatening inflammatory bowel disease in humans and mice—however, the exact mechanism by which IL-10...
具体而言,他们发现IL-10抑制脂多糖诱导的葡萄糖摄取和糖酵解,促进氧化磷酸化。再者,他们还证实IL-10通过诱导一种被称作DDIT4的mTOR抑制剂产生来抑制mTOR活性。相关研究结果发表在2017年5月5日的Science期刊上,论文标题为“Anti-inflammatory effect ofIL-10 mediated by metabolic reprogramming of macrophages”。论文...
IL-10 抗体产品应用WB 成分亲和纯化抗体,20 mM PBS,150 mM NaCl,100 μg/ml BSA,50%甘油,叠氮化钠<0.02% 保存条件-20℃保存 背景资料Interleukin-10, or IL-10, is a 178 amino acid protein that is primarily secreted by TH2 clones. IL-10 is an anti-inflammatory cytokine that is produced by...
IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts . IL-10 is an anti-inflammatory TH2 cytokine that has a critical role in limiting the immune response to pathogens to prevent host damage. As IL-10 in...