Interleukin-6 (IL-6) is a multifunctional cytokine that plays key roles not only in the immune system but also in a variety of biological processes. It is a primary regulator of both acute and chronic inflammations. Moreover, it has proven an excellent target for clinical treatment, as the...
[20] West, Nathaniel R., et al. "Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease." Nature medicine 23.5 (2017): 579-589. [21] Ito, Hiroaki. "IL-6 and Crohn's disease." Current Drug ...
Mindray's Interleukin-6 (IL-6) CLIA reagent is a reliable and accurate solution for measuring this important biomarker of inflammation, infection, and immune response. Designed to work seamlessly with Mindray's CL series chemiluminescence immunoassay ana
Each IL-6 family member elicits responses essential to the physiological control of immune homeostasis, haematopoiesis, inflammation, development and metabolism. Accordingly, distortion of these cytokine activities often promotes chronic disease and cancer; the pathological importance of this is exemplified ...
Recombinant human IL-6. 偶联物 Unconjugated 形式 Liquid 浓度 1.0 mg/mL 纯化类型 Protein G 保存液 PBS 内含物 no preservative 保存条件 -20°C 运输条件 Ambient (domestic); Wet ice (international) RRID AB_223481 产品详细信息 P620 detects IL-6 in WB, Flow and ELISA applications with human samp...
Proinflammatory cytokines Il-6 and TNF-α and the development of inflammation in obese subjects. Eur J Med Res. 2010; Nov 4;15 Suppl 2: 120-2.Popko K,Gorska E,Stelmaszczyk Emmel A. Proinflammatory cytokines Il-6 and TNF-α and the development of inflammation in obese subjects[J]....
Inflammation-Induced IL-6 Functions as a Natural Brake on Macrophages and Limits GN 来自 科研支点 喜欢 0 阅读量: 57 作者:M Luig,MA Kluger,B Goerke,M Meyer,OM Steinmetz 摘要: IL-6 can mediate proinflammatory effects, and IL-6 receptor (IL-6R) blockade as a treatment for inflammatory ...
IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and ...
IL-6 and IL-6 receptor expression and modulation during acute inflammation in the rat: Department of Pathology, McMaster University1, Hamilton, Canada; Department of Immunology2, Scripps Clinic & Research Foundation, La Jolla, CA and Allelix Biopharmaceuticals, Inc.3, Mississauga, CanadaShow more...
During inflammation, mIL-6R is cleaved by the metalloprotease ADAM 17 and shed as sIL-6R from activated cells, markedly increasing IL-6 trans-signaling and expanding the sphere of influence of this key cytokine.6,7 Low levels of soluble isoforms of IL-6-R and gp130 normally present in ...