白细胞介素6自身免疫疾病Interleukin 6 (IL-6), which was originally identified as a B-cell differentiation factor, is now known to be a multifunctional cytokine that regulates the immune response, hematopoiesis, the acute phase response, and inflammation. Deregulation of IL-6 production is implicated...
IL-6与多发性骨髓瘤的发展和进展有关,IL-6可以通过PD-L1的上调诱导骨髓细胞的免疫抑制特性和Arg-1表达以及ROS和NO产生,同时,IL-6能够下调抗原呈递骨髓细胞的功能,因此抑制IL-6信号通路可以是治疗策略的一部分。 图5. IL-6诱导的骨髓细胞免疫抑制[6] ④癌症治疗 IL-6与某些肿瘤的发展和转移有关,因此IL-6信...
New data highlight the contribution of IL-6 to vascular calcification in chronic inflammation. Given that increased vascular calcification and accelerated atherosclerosis occur in patients with chronic inflammatory diseases, new therapies that block the IL-6 pathway might reduce the risk of cardiovascular...
下面这篇研究"Replenishing decoy extracellular vesicles inhibits phenotype remodeling of tissue-resident cells in inflammation-driven arthritis"(IF 14.3)就给出了一个很漂亮的回答,直击临床痛点,照着这个思路准备国自然,也能让国自然申请时更有优势。 01、文章总体背景 白细胞介素-6(IL-6)对于大家来讲都不陌生...
In both diseases CD4+ T cells at the site of inflammation are critically dependent on antiapoptotic IL-6 signaling. Thereby, IL-6 induces the transcriptio 展开 关键词: inflammatory bowel disease IL-6 IL-17 trans signaling colitis DOI: 10.1002/ibd.20148 被引量: 503 ...
FACS analysis of mouse spleen cells revealed proinflammatory macrophages express the highest levels of IL-6Rα, and in vitro treatment with IL-6 blocked macrophage proliferation. Furthermore, proinflammatory macrophages were expanded during inflammation in IL-6 -/- mice. Late application of anti-IL-...
Inflammation in malignant pleural mesothelioma: Interleukin-6 (IL-6) and its relationship to serum parametersInflammation in malignant pleural mesothelioma: Interleukin-6 (IL-6) and its relationship to serum parametersHumansTuberculosis, PulmonaryMesotheliomaAdenocarcinoma...
PP2 A and its subunit B56α were significantly decreased at 1 d and 3d post-surgery and restored to normal levels at week 3. Taken together, the newborn mice have the ability to regenerate the heart completely. And IL-6-mediated early acute inflammation iscritical in cardiomyocyte ...
IL-6 trans-signaling system in intra-amniotic inflammation, preterm birth, and preterm premature rupture of the membranes Classic IL-6 signaling is conditioned by the transmembrane receptor (IL-6R) and homodimerization of gp130. During trans-signaling, IL-6 binds to soluble IL... SF Thung,EF ...
Mindray's Interleukin-6 (IL-6) CLIA reagent is a reliable and accurate solution for measuring this important biomarker of inflammation, infection, and immune response. Designed to work seamlessly with Mindray's CL series chemiluminescence immunoassay ana