Benihoud, K., Salone, B., Esselin, S., Opolon, P., Poli, V., DiGiovine, M., Perricaudet, M., and Saggio, I. The role of IL-6 in the inflammatory and humoral response to adenoviral vectors. J. Gene Med., 2: 194 -203, 2000....
图7.细胞因子风暴的病理机制和使用托珠单抗通过IL-6阻断治疗[3] 以上,是小E老师分享给大家的关于多功能细胞因子IL-6的相关知识。想看更多精彩内容,请持续关注Elabscience®~ 参考文献: [1]Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and diseas[J]. Cold Spring Harb Perspect Bio...
白介素-6(IL-6)是一种非冗余细胞因子,参与T辅助细胞17(TH17)细胞的分化。幼稚T细胞通过其膜结合IL-6受体(IL-6R)感知IL-6; IL-6阻止了转化生长因子-β(TGFβ)介导的FOXP3的诱导,并促进了视黄酸受体相关的孤儿核受体γ(ROR-γt)(TH17的主要转录因子)的表达细胞。然而,仅当树突状细胞(DC)将IL-6转染至T...
[6] Botelho, Fernando M., et al. "Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL- 6 in OSM-driven pulmonary inflammation." The Journal of Immunology 191.3 (2013): 1453-1464.[7] Mosley, Bruce, et al. "Dual ...
白细胞介素6(IL-6)是一种白介素,既可作为促炎性细胞因子,又可作为抗炎性肌因子。在人类中,它是由IL6基因编码的。 另外,成骨细胞分泌IL-6以刺激破骨细胞形成。许多血管的中膜平滑肌细胞也产生IL-6作为促炎性细胞因子。IL-6作为抗炎性肌动蛋白的作用是通过其对TNF-α和IL-1的抑制作用以及IL-1ra和IL-10...
白细胞介素6(IL-6)是一种白介素,既可作为促炎性细胞因子,又可作为抗炎性肌因子。在人类中,它是由IL6基因编码的。 另外,成骨细胞分泌IL-6以刺激破骨细胞形成。许多血管的中膜平滑肌细胞也产生IL-6作为促炎性细胞因子。IL-6作为抗炎性肌动蛋白的作用是通过其对TNF-α和IL-1的抑制作用以及IL-1ra和IL-10...
图7.细胞因子风暴的病理机制和使用托珠单抗通过IL-6阻断治疗[3] 以上,是分享给大家的关于多功能细胞因子IL-6的相关知识。想看更多精彩内容,请持续关注Elabscience®~ 参考文献: [1] Tanaka T, Narazaki M, Kishimoto T. IL-6 in inflammation, immunity, and diseas[J]. Cold Spring Harb Perspect Biol. ...
[6] Botelho, Fernando M., et al. "Pulmonary expression of oncostatin M (OSM) promotes inducible BALT formation independently of IL-6, despite a role for IL- 6 in OSM-driven pulmonary inflammation." The Journal of Immunology 191.3 (2013): 1453-1464. ...
The soluble Interleukin 6 receptor: generation and role in inflammation and cancer. Eur. J. Cell Biol. 90, 484–494 (2011). CAS PubMed Google Scholar Jones, S. A. Directing transition from innate to acquired immunity: defining a role for IL-6. J. Immunol. 175, 3463–3468 (2005). ...
While there is cumulative evidence that both IL-6 and TNFα play an important role in inflammation and PCa progression, the regulatory pathways and the immune microenvironment associated with these cytokines are not well understood and deciphering their function will aid in developing new therapeutic ...