肝纤维化(liver fibrosis)是一种进展性的病理状态,若未能得到有效控制,可能进一步发展为肝硬化,最终需要肝脏移植作为唯一的治疗选择。在肝纤维化过程中,肝星状细胞是主要的成纤维细胞类型,发挥着关键作用。 近年来的研究表明,肝星状细胞高表达IL-11RA(IL-11 受体)和糖蛋白130(gp130),并对IL-11有显著响应。具体...
[3] Widjaja AA, Singh BK, Adami E et al. Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. Gastroenterology. 2019 Sep;...
“Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis.”Gastroenterologyvol. 157,3 (2019): 777-792.e14. doi:10.1053/j.gastro.2019.05.002 Journal information: Gastrojournal 非酒精性脂肪性肝炎(NASH)...
IL-11 inhibition offers a promising strategy, with preclinical trials demonstrating its ability to regenerate renal cells, reduce hepatocyte death, and mitigate liver fibrosis. Further research is necessary to fully elucidate the mechanisms of IL-11 inhibition and its therapeutic potential. If successful...
We determined IL-11 expression in the liver, visceral gonadal white adipose tissue (vWAT) and skeletal muscle (gastrocnemius) in mice over a time course of ageing, which revealed progressive up-regulation of IL-11 in all tissues (Fig.1b,cand Extended Data Fig.1a,b). With age, there was...
Reconstitution of IL11cis-signaling in hepatocytes inIL11ra1null mice restores steatohepatitis but not liver fibrosis To complement our loss-of-function experiments using the CKO mice we employed in vivo gain-of-function experiments. To do so, we assessed whether restoring IL11cis-ortrans-signaling...
Therapeutic inhibition of IL11 signalling with a neutralising antibody against IL11RA reversed liver inflammation and fibrosis in NASH. Given the similarities between the HSCs and PSCs and the established role of IL11 as a pro- fibrotic factor in several other tissues [13], we hypothesised that...
5.Accelerated development of liver fibrosis in CCl4-treated rats by the weekly induction of acute phase response episodes: Upregulation of α1(I) procollagen and tissue inhibitor of metalloproteinase-1 mRNAs1This work was supported in part with Grants RO1 AA09231 and RO1 AA10541 from the Natio...
肝纤维化(liver fibrosis)是一种进展性的病理状态,若未能得到有效控制,可能进一步发展为肝硬化,最终需要肝脏移植作为唯一的治疗选择。在肝纤维化过程中,肝星状细胞是主要的成纤维细胞类型,发挥着关键作用。 近年来的研究表明,肝星状细胞高表达IL-11RA(IL-11 受体)和糖蛋白130(gp130),并对IL-11有显著响应。具体...
肝纤维化(liver fibrosis)是一种进展性的病理状态,若未能得到有效控制,可能进一步发展为肝硬化,最终需要肝脏移植作为唯一的治疗选择。在肝纤维化过程中,肝星状细胞是主要的成纤维细胞类型,发挥着关键作用。 近年来的研究表明,肝星状细胞高表达IL-11RA(IL-11 受体)和糖蛋白130(gp130),并对IL-11有显著响应。具体...